Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?
Study Goal
The researchers aimed to summarize current studies on the relationship between melatonin and aging, focusing on its potential role in mitigating age-related diseases and oxidative stress.
Results Summary
The study found that melatonin levels decline with aging and are associated with age-related diseases, oxidative damage, and mitochondrial dysfunction. It suggests melatonin supplementation could be beneficial in COVID-19 treatment for the elderly due to its role in reducing oxidative stress.
Population
Elderly individuals and those with age-related diseases, particularly in the context of COVID-19.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | neutral | biological processes | - | - | influence | #1 |
melatonin rhythms | neutral | biological process of aging | - | - | reflect | #2 |
melatonin levels | decrease | - | with aging | - | decline considerably | #3 |
melatonin decline | neutral | several age-related diseases | - | - | associated with | #4 |
melatonin | decrease | age-related oxidative stress | - | - | plays a pivotal role in preventing | #5 |
melatonin supplementation | neutral | COVID-19 treatment | elderly | - | could be beneficial | #6 |
The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular functions.Melatoninrhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its decline is associated with several age-related diseases. Aging is closely associated with oxidative damage and mitochondrial dysfunction. Free radical reactions initiated by the mitochondria constitute the inherent aging process. Melatonin plays a pivotal role in preventing age-related oxidative stress. Coronavirus disease 2019 (COVID-19) fatality rates increase with chronic diseases and age, where melatonin levels decrease. For this reason, melatonin supplementation in elderly could be beneficial in COVID-19 treatment. Therefore, studies on the usage of melatonin in COVID-19 treatment are needed.