The Effects of Melatonin on the Oxidative Stress and Duration of Atrial Fibrillation after Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial.
Study Goal
The researchers aimed to determine if sublingual melatonin could reduce oxidative stress and inflammation markers (hs-CRP, CK-MB, cTnT) and atrial fibrillation duration in patients undergoing CABG surgery.
Results Summary
Melatonin significantly reduced hs-CRP and CK-MB levels and shortened AF duration post-CABG, but did not affect AF incidence or cTnT levels.
Population
Patients undergoing coronary artery bypass graft (CABG) surgery.
Effective Dosage
12 mg sublingual melatonin the evening before and 1 hour before surgery.
Duration
Administered twice, pre-surgery.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
sublingual consumption of melatonin | decrease | necrosis and inflammation | patients undergoing CABG | - | reducing | #1 |
sublingual consumption of melatonin | decrease | C-reactive protein (hs-CRP) levels | patients undergoing CABG | - | reducing | #2 |
sublingual consumption of melatonin | decrease | Creatine Kinase-Muscle-Brain subunits (CK-MB) levels | patients undergoing CABG | - | reducing | #3 |
sublingual consumption of melatonin | decrease | cardiac Troponin T (cTnT) levels | patients undergoing CABG | - | reducing | #4 |
melatonin | no change | incidence of AF following CABG surgery | patients undergoing CABG | - | was not statistically significant | #5 |
melatonin | decrease | duration of AF | patients undergoing CABG | - | were significantly lower | #6 |
melatonin | decrease | levels of hs-CRP | patients undergoing CABG | - | were significantly lower | #7 |
melatonin | decrease | levels of CK-MB | patients undergoing CABG | - | were significantly lower | #8 |
melatonin | no change | cTnT levels | patients undergoing CABG | - | did not show any significant difference | #9 |
administration of melatonin | decrease | oxidative stress | patients undergoing CABG | - | may help modulate | #10 |
administration of melatonin | decrease | levels of hs-CRP | patients undergoing CABG | - | reduction | #11 |
administration of melatonin | decrease | levels of CK-MB | patients undergoing CABG | - | reduction | #12 |
administration of melatonin | decrease | duration of AF following CABG surgery | patients undergoing CABG | - | reduction | #13 |
BACKGROUND: Atrial Fibrillation (AF) is a common complication following Coronary artery bypass graft (CABG) Surgery, which may be due to oxidative stress, necrosis and inflammation during CABG and can lead to increases the length of hospital stay and the risk of morbidity and mortality. Melatonin is a hormone with anti-oxidant and anti-inflammatory properties in the cardiovascular system. This study assessed the efficacy of sublingual consumption of melatonin in reducing necrosis and inflammation, in patients undergoing CABG with respect to C-reactive protein (hs-CRP), Creatine Kinase-Muscle-Brain subunits (CK-MB) and cardiac Troponin T (cTnT) levels. METHODS: One hundred and two patients were enrolled and twenty-six patients were excluded during the study process and finally seventy-six patients undergoing CABG surgery randomly assigned to melatonin group (n = 38, 12 mg sublingual melatonin the evening before and 1 hour before surgery, or the control group which did not receive Melatonin, n = 38). Three patients in the melatonin group and three patients in the control group were excluded from the study because of discontinued intervention and lost to follow up. The samples were collected before and 24 hours after surgery. hs-CRP, CK-MB, and cTnT levels were measured in all patients with the Elisa method. RESULTS: There was no significant difference in influencing variables among the groups at the baseline. The incidence of AF following CABG surgery was not statistically significant between the two groups, (p-value = 0.71). However, the duration of AF (p-value = 0.01), the levels of hs-CRP (p-value = 0.001) and CK-MB (p-value = 0.004) measured, 24 hours after surgery were significantly lower in the melatonin group. cTnT levels measured 24 hours post-CABG did not show any significant difference in both groups (p-value = 0.52). CONCLUSION: Our findings suggest that the administration of melatonin may help modulate oxidative stress, based on the reduction of the levels of hs-CRP, CK-MB, and the duration of AF following CABG surgery.