Oxidative stress does not influence weight loss induced by aerobic training in adults: randomized clinical trials.
Study Goal
The researchers aimed to determine whether oxidative stress markers (MDA and TAC) influence the magnitude of weight loss induced by aerobic exercise (walking/running) in sedentary overweight or obese individuals.
Results Summary
The experimental group showed significant reductions in fat mass, total body mass, BMI, and fat percentage, along with increased MDA levels, but no changes in TAC. No correlation was found between oxidative stress markers and weight loss outcomes.
Population
Sedentary overweight or obese adults (N=75).
Effective Dosage
Aerobic training (walking/running) 3-5 days/week.
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
a 12-week program of aerobic training walking and/or running | decrease | fat body mass | previously sedentary overweight or obese individuals | -1.3±1.9 kg versus -0.3±1.3 kg in control group | Significant reduction was found | #1 |
a 12-week program of aerobic training walking and/or running | decrease | total body mass | previously sedentary overweight or obese individuals | -1.2±4.7 kg; effect size 0.44 | altered significantly | #2 |
a 12-week program of aerobic training walking and/or running | decrease | body mass index - BMI | previously sedentary overweight or obese individuals | -0.3±1.1; effect size 0.37 | altered significantly | #3 |
a 12-week program of aerobic training walking and/or running | decrease | fat percentage | previously sedentary overweight or obese individuals | 1.3±1.6%; effect size 0.50 | altered significantly | #4 |
a 12-week program of aerobic training walking and/or running | increase | lean body mass | previously sedentary overweight or obese individuals | 0.6±1.5 kg; effect size 0.32 | altered significantly | #5 |
a 12-week program of aerobic training walking and/or running | increase | MDA | previously sedentary overweight or obese individuals | 2.3 μmol/L to 2.7 μmol/L | There was increase | #6 |
a 12-week program of aerobic training walking and/or running | no change | TAC | previously sedentary overweight or obese individuals | 25.6±13.9% to 28.0±10.4% | without changes | #7 |
a 12-week program of aerobic training walking and/or running | no change | variations in body composition | previously sedentary overweight or obese individuals | - | No correlation was found | #8 |
a 12-week program of aerobic training walking and/or running | no change | variations in body composition | previously sedentary overweight or obese individuals | - | No correlation was found | #9 |
a 12-week program of aerobic training walking and/or running | no change | magnitude of weight-loss | previously sedentary overweight or obese individuals | - | does not influence | #10 |
BACKGROUND: High levels of oxidative stress promote degradation of the cell membrane impairing cellular function in fat oxidation. However, the influence of oxidative stress on exercise-induced weight-loss has not yet been investigated. Therefore, the aim of this study was to verify the influence of a lipidic peroxidation marker (malondialdehyde, MDA) and antioxidant status (total antioxidant capacity marker, TAC) on the magnitude of weight-loss by aerobic-induced exercise in previously sedentary overweight or obese individuals. METHODS: Seventy-five physically inactive adults were randomized into experimental (N.=58) and control (N.=17) groups, who engaged in a 12-week program of aerobic training walking and/or running (3 to 5 days/week) or stretching (1 day/week), respectively. Body composition (DXA), aerobic capacity (ergospirometric) and blood collections for oxidative stress analysis (MDA and TAC) were determined before and after the experimental protocol. Two-way ANOVA for repeated measures or Friedman's test were used to evaluate differences in time/group interaction. Pearson correlation was used to verify the relationship between the variables of oxidative stress and of body composition. RESULTS: Significant reduction was found in fat body mass of experimental when compared to control group (-1.3±1.9 kg versus -0.3±1.3, P=0.04). Experimental group also altered significantly the total body mass (-1.2±4.7 kg; effect size 0.44), body mass index - BMI (-0.3±1.1 effect size 0.37), fat percentage (1.3±1.6%; effect size 0.50) and lean body mass (0.6±1.5 kg; effect size 0.32).There was increase in MDA of 2.3 μmol/L to 2.7 μmol/L (P=0.00), without changes to TAC (25.6±13.9% to 28.0±10.4%). No correlation was found between these variations in body composition with either the initial values of MDA and TAC or delta variation of these indicators of oxidative stress in response to the training program. CONCLUSIONS: Indicators of oxidative stress (MDA and TAC) does not influence the magnitude of weight-loss induced by aerobic training.