Trace element nanoparticles improved diabetes mellitus; a brief report.
Study Goal
The researchers aimed to investigate the antidiabetic effects of copper nanoparticles and their mechanism of action in managing diabetes and its complications.
Results Summary
The study found that copper has antidiabetic effects, improving diabetes-induced complications by increasing antioxidant enzyme levels, glucose utilization, and insulin sensitivity. Copper nanoparticles were noted to be more potent than other forms for diabetes treatment.
Population
Not specified (general diabetes-related complications).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
zinc | decrease | diabetes | - | - | have antidiabetic effects | #1 |
copper | decrease | diabetes | - | - | have antidiabetic effects | #2 |
selenium | decrease | diabetes | - | - | have antidiabetic effects | #3 |
magnesium | decrease | diabetes | - | - | have antidiabetic effects | #4 |
zinc, copper, selenium, and magnesium | decrease | diabetes-induced complications | - | - | improved | #5 |
zinc, copper, selenium, and magnesium | increase | antioxidant enzyme level | - | - | increase | #6 |
zinc, copper, selenium, and magnesium | increase | glucose utilization | - | - | increase | #7 |
zinc, copper, selenium, and magnesium | increase | insulin sensitivity | - | - | increase | #8 |
zinc nanoparticles | decrease | diabetes | - | - | were more potent for the treatment | #9 |
copper nanoparticles | decrease | diabetes | - | - | were more potent for the treatment | #10 |
selenium nanoparticles | decrease | diabetes | - | - | were more potent for the treatment | #11 |
magnesium nanoparticles | decrease | diabetes | - | - | were more potent for the treatment | #12 |
BACKGROUND: Diabetes mellitus is a chronic metabolic disease that induces several complications in various organs such as the liver, kidney, and reproductive system. Trace elements such as copper, zinc, selenium, and magnesium play an essential role in the management or treatment of diabetes mellitus. AIM: the aim of the present study was conducted to investigate the effect of these trace elements nanoparticles and their probable mechanism of action on diabetes and its complications. METHODS: The present brief report was conducted with a search of articles published in several databases including PubMed, ScienceDirect, Google Scholar, and Scopus. The articles were selected from 2011 to 2018 using the keywords "zinc," "copper," "selenium," "magnesium," and "diabetes." Following the eligibility criteria were selected 16 articles and 1 book. RESULTS: The scientific results of the presented brief report show that zinc, copper, selenium, and magnesium have antidiabetic effects. Also, they improved the diabetes-induced complications through increase antioxidant enzyme level, glucose utilization, and insulin sensitivity. CONCLUSION: While zinc, copper, selenium, and magnesium revealed antidiabetic effects, but their nanoparticles were more potent for the treatment of this disease.