Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study.
Study Goal
The researchers aimed to assess celiac disease screening rates and the impact of a gluten-free diet on glycemic outcomes in asymptomatic patients with type 1 diabetes.
Results Summary
The study found that celiac disease was frequently observed in asymptomatic type 1 diabetes patients. A gluten-free diet was associated with changes in HbA1c, though specific outcomes were not detailed in the abstract.
Population
Asymptomatic patients with type 1 diabetes, aged 8-45 years.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
gluten-free diet | no change | HbA1c | asymptomatic patients with type 1 diabetes and biopsy-confirmed celiac disease | no significant change | no significant change | #1 |
gluten-free diet | no change | hypoglycemia | asymptomatic patients with type 1 diabetes and biopsy-confirmed celiac disease | no significant change | no significant change | #2 |
gluten-free diet | no change | glycemic variability | asymptomatic patients with type 1 diabetes and biopsy-confirmed celiac disease | no significant change | no significant change | #3 |
gluten-free diet | no change | insulin requirements | asymptomatic patients with type 1 diabetes and biopsy-confirmed celiac disease | no significant change | no significant change | #4 |
gluten-free diet | no change | quality of life | asymptomatic patients with type 1 diabetes and biopsy-confirmed celiac disease | no significant change | no significant change | #5 |
- | increase | CD-seropositivity rates | adults | 6.8% | higher | #6 |
- | decrease | CD-seropositivity rates | children | 1.6% | lower | #7 |
OBJECTIVE: To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD. RESEARCH DESIGN AND METHODS: Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA RESULTS: Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%, CONCLUSIONS: CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD.