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The alteration of stress-related physiological parameters after probiotics administration in oral surgeons with different degrees of surgical experience.

La Clinica terapeutica
January 1, 2020
A Pacifici et al. (13 authors)
Journal ArticleRandomized Controlled TrialHuman StudyClinical
Study Details

Study Goal

The researchers aimed to evaluate the efficacy of a specific probiotics formula on stress levels in oral and maxillofacial surgeons to improve their quality of life.

Results Summary

The study found that 10 weeks of probiotic use improved stress-related physiological parameters like salivary cortisol and immunoglobulin levels but did not significantly affect cardiovascular parameters. Probiotics increased IgA levels compared to placebo, suggesting immune modulation.

Population

40 oral and maxillofacial surgeons categorized by experience level (senior, expert, junior).

Effective Dosage

Not specified

Duration

10 weeks

Interactions

None mentioned

Extracted Claims (6)
InterventionDirectionEndpointPopulationDosageImpactClaim #
probiotics strains formula
no change
cardiovascular parameters
oral and maxillofacial surgeons
null
not significantly modified
#1
10 weeks of probiotic integration
decrease
salivary cortisol levels
oral surgeons with different degrees of surgical experience
null
may induce the improvement
#2
probiotics administration
increase
immunoglobulin levels
test group
null
were higher
#3
regular use of probiotics
increase
IgA producing cells
null
null
may induce an increased number
#4
10 weeks of probiotics-enriched diet
null
some stress-related physiological parameters
oral surgeons with different degrees of surgical experience
null
modify
#5
10 weeks of probiotics-enriched diet
no change
overall cardiovascular risk
oral surgeons with different degrees of surgical experience
null
does not impact
#6
Abstract

PURPOSE: Stress is a multifactorial and complex pathway, gaining growing attention from the healthcare community. Surgeons are subjected to higher levels of stress, due to surgical procedures that are demanding and repetitive; unfortunately, high-stress levels may also cause side-effects, as surgical mistakes. This study aimed to evaluate the efficacy of specific probiotics strains formula on stress levels in oral and maxillofacial surgeons, to improve their quality of life. METHODS: We have investigated the hormonal (salivary Cortisol; sC), immune (salivary Immunoglobulin A; sIgA) and cardiovascular (Heart rate, HR, and systolic blood pressure, SBP) responses induced by stress conditions in 40 oral surgeons, randomly selected and allocated, according to their experience level, in three categories: senior, expert, and junior. RESULTS: The results described how the number of heartbeats/ minute and SBP are slightly raised in all surgeons at different timepoints. Such data allow us to assess that work-related stress can induce an increase in cardiovascular parameters, even if they are not significantly modified by the use of probiotics. On the other hand, our data indicate that 10 weeks of probiotic integration may induce the improvement of other stress-related physiological parameters in oral surgeons with different degrees of surgical experience, such as the salivary cortisol levels, even under stress conditions. Moreover, in the test group (probiotics administration), the immunoglobulin levels were higher than the control (placebo administration) group: this happens as a consequence of the regular use of probiotics, which may induce an increased number of IgA producing cells. DISCUSSION: Our data indicated that 10 weeks of probiotics-enriched diet modify some stress-related physiological parameters in oral surgeons with different degrees of surgical experience, but it does not impact on the overall cardiovascular risk.

Medical Subject Headings (MeSH)
AdultBlood PressureClinical CompetenceDouble-Blind MethodHeart RateHumansHydrocortisoneMaleMiddle AgedOral and Maxillofacial SurgeonsProbioticsQuality of LifeSalivaStress, Physiological
Study Links
Quality Scores
SafetyNot Assessed
Efficacy70/10
Quality75/10
Citation Metrics
Total Citations10
Citations/Year2.0
Relative Citation Ratio0.94
NIH Percentile47.9%
Research Impact Scores
APT Score0.50
Weight Score2.22
Normalized Score0.63
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