Impact of healthy diet and physical activity on metabolic health in men and women: Study Protocol Clinical Trial (SPIRIT Compliant).
Study Goal
The researchers aimed to examine the impacts of healthy dietary patterns alone or combined with physical activity on metabolic health in middle-aged and older adults.
Results Summary
The study protocol describes a randomized controlled trial to assess changes in metabolic and inflammatory health biomarkers, body composition, and perceived health, but results are not yet available (pre-results).
Population
Middle-aged and older adults (55-70 years) without overt disease, BMI below 35, low fruit/vegetable intake, and noncompliance with physical activity guidelines.
Effective Dosage
5 servings of fruits and vegetables per day (equivalent to 500 g).
Duration
16 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Healthy Diet (HD) | neutral | metabolic health | middle-aged and older men and women | - | aiming to examine the impacts | #1 |
Healthy diet plus PA (HD-PA) | neutral | metabolic health | middle-aged and older men and women | - | aiming to examine the impacts | #2 |
Healthy Diet (HD) | increase | fruit and vegetable intake | Participants in HD | 5 servings per day (equivalent to 500 g) | instructed to increase | #3 |
Healthy diet plus PA (HD-PA) | increase | fruit and vegetable intake | Participants in HD-PA | 5 servings per day (equivalent to 500 g) | instructed to increase | #4 |
Healthy diet plus PA (HD-PA) | increase | moderate-to-vigorous physical activities | Participants in HD-PA | at least 150 minutes per week | additionally instructed to engage in | #5 |
INTRODUCTION: Healthy dietary patterns and physical activity (PA) represent important lifestyle behaviors with considerable potential to influence on age-related metabolic health. Yet, data on the combined effects of these lifestyle behaviors on metabolic health including low-grade systemic inflammation in aging populations remain scarce. Therefore, this protocol describes a randomized controlled trial aiming to examine the impacts of healthy dietary patterns alone or combined with PA on metabolic health in middle-aged and older men and women. MATERIAL AND METHODS: The ORUDIET study is a 3-arm randomized controlled 16-week trial: Healthy Diet (HD), Healthy diet plus PA (HD-PA), and control (CON). The trial is open label, randomized with allocation concealment, parallel groups with passive controls. Participants without overt disease aged between 55 and 70 years, with BMI below 35, a current intake of a maximum of 1 serving of fruit and vegetable per day, and noncompliance to PA guidelines are eligible for inclusion. Participants in HD are instructed to increase fruit and vegetable intake to 5 servings per day (equivalent to 500 g). Participants in HD-PA receive the same dietary intervention as the HD and are additionally instructed to engage in moderate-to-vigorous physical activities for at least 150 minutes per week. The primary study outcomes are changes in metabolic and inflammatory health biomarkers. Secondary outcomes are changes in body composition and perceived health. ETHICS AND DISSEMINATION: The study protocol has been approved by the ethical review board in Uppsala, Sweden. The results will be published in peer-reviewed journals and disseminated in national and international conferences. TRIAL REGISTRATION NUMBER: NCT04062682 Pre-results.