The Positive Effects of a Calorie-Restricting High-Protein Diet Combined with Intragastric Botulinum Toxin Type A Application Among Morbidly Obese Patients: A Prospective, Observational Analysis of Eighty-Seven Grade 2 Obese Patients.
Study Goal
The researchers aimed to evaluate the effects of combining intragastric botulinum toxin type A injection (IG-BTxA) with a calorie-restricting high-protein diet on weight loss and comorbid conditions in obese patients.
Results Summary
The study found that combining IG-BTxA with a high-protein diet resulted in significantly greater weight loss, better treatment adaptation, and positive behavioral changes in eating preferences compared to either intervention alone. Additionally, the combination led to reduced medication requirements for diabetes and hypertension.
Population
Grade 2 obese patients (n=87) treated between January 2019 and August 2019.
Effective Dosage
Not specified
Duration
7 months (January 2019 to August 2019)
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
IG-BTxA + get calorie-restricting high-protein diet | increase | Loss of weight | grade 2 obese patients | - | were significantly higher | #1 |
IG-BTxA + get calorie-restricting high-protein diet | increase | treatment adaptation | grade 2 obese patients | - | were significantly higher | #2 |
IG-BTxA + get calorie-restricting high-protein diet | increase | positive behavioral change in eating preferences | grade 2 obese patients | - | were significantly higher | #3 |
IG-BTxA + get calorie-restricting high-protein diet | increase | decrease in medication requirement for diabetes and hypertension | grade 2 obese patients | - | was higher | #4 |
IG-BTxA application before calorie-restricting high-protein diet | increase | adaptation to the new diet style | grade 2 obese patients | - | facilitates adaptation | #5 |
IG-BTxA application before calorie-restricting high-protein diet | increase | weight loss | grade 2 obese patients | - | helps to lose weight faster | #6 |
IG-BTxA application before calorie-restricting high-protein diet | increase | controlling comorbid diseases | grade 2 obese patients | - | more positive results were achieved | #7 |
PURPOSE: Many studies evaluating the effect of intragastric botulinum toxin type A injection (IG-BTxA) for the treatment of obesity have been published. However, none of these studies combined this procedure with a calorie-restricting high-protein diet. Herein, we aimed to evaluate the effects of IG-BTxA application combined with a calorie-restricting high-protein diet. MATERIALS AND METHODS: This prospective cohort study is conducted with eighty-seven grade 2 obese patients treated between January 2019 and August 2019. Group 1: IG-BTxA + refused to consult the dietitian; group 2: IG-BTxA + get calorie-restricting high-protein diet; group 3: only get a calorie-restricting high-protein diet. Loss of weight, treatment adaptation (visual analog scale score), the status and changes of comorbid conditions, and changes in eating behaviors (Self-Regulation of Eating Behaviour Questionnaire score) were assessed. RESULTS: Loss of weight, treatment adaptation, and positive behavioral change in eating preferences were significantly higher in group 2 (p = 0.01; p = 0.001; p < 0.01, respectively). Additionally, the decrease in medication requirement for diabetes and hypertension was higher in group 2 (p < 0.05). CONCLUSION: IG-BTxA application before calorie-restricting high-protein diet facilitates adaptation to the new diet style and helps to lose weight faster in grade 2 obese patients. Also, more positive results were achieved in terms of controlling comorbid diseases.