Quality of Life: Psychological Symptoms-Effects of a 2-Month Healthy Diet and Nutraceutical Intervention; A Randomized, Open-Label Intervention Trial (RISTOMED).
Study Goal
The researchers aimed to determine the effects of a healthy diet, alone or combined with additional supplements, on health-related quality of life, anxiety, and depressive symptoms in older adults, particularly in relation to inflammation status.
Results Summary
The study found that a healthy diet intervention reduced depressive symptoms across all groups, with significant decreases in CES-D scores, particularly in subjects with medium/high inflammation. Mental component summary of HRQoL improved in some groups, but there were no changes in anxiety or physical HRQoL.
Population
Healthy older adults aged 65-80 years from Italy, France, and Germany.
Effective Dosage
Not specified (healthy diet composition described but no exact dosage provided for the diet or supplements).
Duration
56 days.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
multicenter dietary intervention | decrease | inflammation | older people | - | was shown to reduce | #1 |
Healthy diet (HD) | decrease | CES-D score | healthy older subjects (65-80 year) | -40.0% | A decrease of CES-D score was seen | #2 |
HD plus De Simone Formulation probiotic blend | decrease | CES-D score | healthy older subjects (65-80 year) | -32.5% | A decrease of CES-D score was seen | #3 |
HD plus AISA d-Limonene | decrease | CES-D score | healthy older subjects (65-80 year) | -42.8% | A decrease of CES-D score was seen | #4 |
HD plus Argan oil | decrease | CES-D score | healthy older subjects (65-80 year) | -33.3% | A decrease of CES-D score was seen | #5 |
Healthy diet (HD) | decrease | CES-D score | subjects with medium/high inflammation | -44.8% | a similar decrease in CES-D score occurred | #6 |
HD plus De Simone Formulation probiotic blend | decrease | CES-D score | subjects with medium/high inflammation | -46.7% | a similar decrease in CES-D score occurred | #7 |
HD plus AISA d-Limonene | decrease | CES-D score | subjects with medium/high inflammation | -52.2% | a similar decrease in CES-D score occurred | #8 |
HD plus Argan oil | decrease | CES-D score | subjects with medium/high inflammation | -43.8% | a similar decrease in CES-D score occurred | #9 |
interventions | no change | baseline inflammation | - | - | was not related to | #10 |
Healthy diet (HD) | increase | MCS-HRQoL | - | - | MCS-HRQoL improved | #11 |
HD plus AISA d-Limonene | increase | MCS-HRQoL | - | - | MCS-HRQoL improved | #12 |
- | no change | anxiety | - | - | There was no change | #13 |
- | no change | PCS-HRQoL | - | - | There was no change | #14 |
healthy diet intervention | decrease | depressive symptoms | healthy older volunteers | - | a decrease in depressive symptoms was observed | #15 |
Depression symptoms and lower health-related quality of life (HRQoL) are associated with inflammation. This multicenter dietary intervention was shown to reduce inflammation in older people. This was the main outcome. Here, we describe the effects on HRQoL, anxiety, and depressive symptoms according to inflammation status. Overall, 125 healthy older subjects (65-80 year) were recruited (Italy, France, and Germany) and randomized into four arms (A, Healthy diet (HD); B, HD plus De Simone Formulation probiotic blend; C, HD plus AISA d-Limonene; D, HD plus Argan oil). The HD was weight maintaining, rich in antioxidant vitamins, polyphenols, polyunsaturated fatty acids (n6: n3 ratio = 3:1), and fiber. Data on inflammatory parameters, mental (MCS) and physical (PCS) component summaries of HRQoL (SF-36), anxiety symptoms (STAI state), and depressive symptoms (CES-D) were collected before and after 56 days of intervention. Body fat mass proportion (BFM) was considered a co-variable. A decrease of CES-D score was seen in the four arms (A: -40.0%, p = 0.001; B: -32.5%, p = 0.023; C: -42.8%, p = 0.004; and D: -33.3%, p = 0.21). Within the subgroups of subjects with medium/high inflammation a similar decrease in CES-D score occurred in all groups (A: -44.8%, p = 0.021; B, -46.7%, p = 0.024; C, -52.2%, p = 0.039; D, -43.8%, p = 0.037). The effect of interventions on CES-D was not related to baseline inflammation. MCS-HRQoL improved in A and C. There was no change in anxiety or PCS-HRQoL. In this trial with no control group, a decrease in depressive symptoms in healthy older volunteers was observed after a 2-month healthy diet intervention, independently of inflammation but with possible limitations due to participation.