Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment.
Study Goal
The researchers aimed to evaluate the effectiveness of oral multivitamins and multi/minerals (OMVMs), including antioxidants, for the treatment and prevention of cardiovascular diseases (CVD).
Results Summary
The study found no consistent benefit of multivitamins, vitamin C and D, coenzyme Q, calcium, or selenium for CVD prevention, myocardial infarction, stroke, or all-cause mortality. Folic acid alone and B vitamins with folic acid showed some potential, but the overall efficacy was limited.
Population
Not specified (general population with CVD risk or patients with CVD).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
multivitamins | no change | prevention of CVD | - | no consistent benefit | showed no consistent benefit | #1 |
multivitamins | no change | prevention of myocardial infarction | - | no consistent benefit | showed no consistent benefit | #2 |
multivitamins | no change | prevention of stroke | - | no consistent benefit | showed no consistent benefit | #3 |
multivitamins | no change | all-cause mortality | - | no benefit | showed no benefit | #4 |
vitamin C | no change | prevention of CVD | - | no consistent benefit | showed no consistent benefit | #5 |
vitamin C | no change | prevention of myocardial infarction | - | no consistent benefit | showed no consistent benefit | #6 |
vitamin C | no change | prevention of stroke | - | no consistent benefit | showed no consistent benefit | #7 |
vitamin C | no change | all-cause mortality | - | no benefit | showed no benefit | #8 |
vitamin D | no change | prevention of CVD | - | no consistent benefit | showed no consistent benefit | #9 |
vitamin D | no change | prevention of myocardial infarction | - | no consistent benefit | showed no consistent benefit | #10 |
vitamin D | no change | prevention of stroke | - | no consistent benefit | showed no consistent benefit | #11 |
vitamin D | no change | all-cause mortality | - | no benefit | showed no benefit | #12 |
coenzyme Q | no change | prevention of CVD | - | no consistent benefit | showed no consistent benefit | #13 |
coenzyme Q | no change | prevention of myocardial infarction | - | no consistent benefit | showed no consistent benefit | #14 |
coenzyme Q | no change | prevention of stroke | - | no consistent benefit | showed no consistent benefit | #15 |
coenzyme Q | no change | all-cause mortality | - | no benefit | showed no benefit | #16 |
calcium | no change | prevention of CVD | - | no consistent benefit | showed no consistent benefit | #17 |
calcium | no change | prevention of myocardial infarction | - | no consistent benefit | showed no consistent benefit | #18 |
calcium | no change | prevention of stroke | - | no consistent benefit | showed no consistent benefit | #19 |
calcium | no change | all-cause mortality | - | no benefit | showed no benefit | #20 |
selenium | no change | prevention of CVD | - | no consistent benefit | showed no consistent benefit | #21 |
selenium | no change | prevention of myocardial infarction | - | no consistent benefit | showed no consistent benefit | #22 |
selenium | no change | prevention of stroke | - | no consistent benefit | showed no consistent benefit | #23 |
selenium | no change | all-cause mortality | - | no benefit | showed no benefit | #24 |
PURPOSE OF REVIEW: The objective of this study is to explore the current literature supporting the use oral multivitamins and multi/minerals (OMVMs) for cardiovascular diseases (CVD) treatment and prevention. RECENT FINDINGS: Data on multivitamins, vitamin C and D, coenzyme Q, calcium, and selenium, has showed no consistent benefit for the prevention of CVD, myocardial infarction, or stroke, nor was there a benefit for all-cause mortality to support their routine supplementation. Folic acid alone and B vitamins with folic acid, B