Effect of high-dose vitamin D supplementation in combination with weight loss diet on glucose homeostasis, insulin resistance, and matrix metalloproteinases in obese subjects with vitamin D deficiency: a double-blind, placebo-controlled, randomized clinical trial.
Study Goal
The researchers aimed to examine the effect of vitamin D supplementation on glucose homeostasis, insulin resistance, and matrix metalloproteinases in obese subjects with vitamin D deficiency.
Results Summary
The abstract does not provide results regarding Calcium's effects.
Population
Obese subjects with vitamin D deficiency (serum 25(OH)D ≤ 50 nmol/L and BMI 30-40 kg/m²).
Effective Dosage
Not provided
Duration
Not provided
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation | neutral | glucose homeostasis | obese subjects with vitamin D deficiency | - | examine the effect | #1 |
vitamin D supplementation | neutral | insulin resistance | obese subjects with vitamin D deficiency | - | examine the effect | #2 |
vitamin D supplementation | neutral | matrix metalloproteinases | obese subjects with vitamin D deficiency | - | examine the effect | #3 |
As there is limited and inconsistent evidence in potential role of vitamin D on insulin resistance and matrix metalloproteinases, this study aimed to examine the effect of vitamin D supplementation on glucose homeostasis, insulin resistance, and matrix metalloproteinases in obese subjects with vitamin D deficiency. A total of 44 participants with serum 25-hydroxyvitamin D (25(OH)D) level ≤ 50 nmol/L and body mass index (BMI) 30-40 kg