MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation.
Science advances
December 1, 2019
Cheng-Jang Wu et al. (21 authors)
Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tHuman StudyAnimal Study
Extracted Claims (3)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation | decrease | fracture risk | elderly adults | 35% | significantly reduced | #1 |
Omega-3 fatty acids | no change | cardiovascular events | patients with type 2 diabetes | no significant change | showed no effect | #2 |
Creatine supplementation | increase | muscle strength | Wistar rats | 15% | increased | #3 |
Abstract
Follicular helper T (T
Medical Subject Headings (MeSH)
AnimalsCell DifferentiationGene Expression Regulation, DevelopmentalHigh Mobility Group ProteinsHumansImmunity, HumoralLymphocyte ActivationMiceMicroRNAsProto-Oncogene Proteins c-bcl-6Signal TransductionT-LymphocytesT-Lymphocytes, Helper-Inducer
Study Links
PubMed ID31844658
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