Melatonin in the treatment of fibromyalgia symptoms: A systematic review.
Study Goal
The researchers aimed to systematically review the impact of melatonin on fibromyalgia symptoms, including disease impact, pain, sleep quality, and other related factors.
Results Summary
All included studies reported positive effects of melatonin on fibromyalgia symptoms, with no major adverse events reported. However, significant heterogeneity between studies was noted, indicating a need for further high-quality trials.
Population
Fibromyalgia patients (98 participants across four studies).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | decrease | FM symptoms | FM patients | - | positive effect | #1 |
melatonin | no change | adverse events | FM patients | - | no major adverse event | #2 |
The available pharmacological modalities for the treatment of fibromyalgia (FM) are associated with a variety of adverse effects and limited benefits. In this study, we systematically reviewed the impact of melatonin in the treatment of FM. Interventional studies, either controlled or uncontrolled and randomized or non-randomized, were included. PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library were searched without time limitation. Primary outcome measures were the effect of melatonin on the disease impact, pain, sleep quality, tender point count, fatigue, anxiety, stiffness, and depression in FM patients. Four studies, reporting the effect of melatonin on 98 patients, were eligible to include. All the studies reported the positive effect of melatonin on the FM symptoms. No major adverse event was reported. A significant level of heterogeneity was observed between the studies. Therefore, further high-quality controlled clinical trials are needed to understand the role of melatonin in FM treatment fully.