Diet quality, dietary inflammatory index and body mass index as predictors of response to adjunctive
Study Goal
The researchers aimed to explore the relationships between diet quality, dietary inflammatory potential, body mass index, and outcomes of a nutraceutical treatment (including N-Acetylcysteine) for bipolar depression.
Results Summary
The study found no significant prediction of depression score changes by diet quality, inflammatory index, or BMI in participants taking combination treatment (including N-Acetylcysteine) versus placebo. However, better diet quality was associated with reduced general and bipolar depression symptoms.
Population
Participants with bipolar depression.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
combination treatment | no change | change in depression scores | participants with bipolar depression | - | was not predicted by | #1 |
Australian Recommended Food Score | no change | change in depression scores | participants taking combination treatment compared to placebo | - | was not predicted by | #2 |
dietary inflammatory index | no change | change in depression scores | participants taking combination treatment compared to placebo | - | was not predicted by | #3 |
body mass index | no change | change in depression scores | participants taking combination treatment compared to placebo | - | was not predicted by | #4 |
better diet quality (Australian Recommended Food Score) | decrease | general depression and bipolar depression symptoms | participants | - | reported reduced | #5 |
AIMS: We aimed to explore the relationships between diet quality, dietary inflammatory potential or body mass index and outcomes of a clinical trial of nutraceutical treatment for bipolar depression. METHODS: This is a sub-study of a randomised controlled trial of participants with bipolar depression who provided dietary intake data ( RESULTS: In participants taking combination treatment compared to placebo, change in depression scores was not predicted by Australian Recommended Food Score, dietary inflammatory index or body mass index scores. However, participants with better diet quality (Australian Recommended Food Score) reported reduced general depression and bipolar depression symptoms ( CONCLUSION: These data support a possible association between diet (quality and inflammatory potential), body mass index and response to treatment for bipolar depression in the context of a nutraceutical trial. The results should be interpreted cautiously because of limitations, including numerous null findings, modest sample size and being secondary analyses.