The Crosstalk of miRNA and Oxidative Stress in the Liver: From Physiology to Pathology and Clinical Implications.
Study Goal
The researchers aimed to review the metabolic changes in the liver caused by a high-fat diet, focusing on miRNA alterations, reactive oxygen species, and their interplay in liver diseases.
Results Summary
The study found that high-fat diets contribute to liver diseases by altering miRNA expression and increasing oxidative stress, which affects signaling and metabolic pathways. These changes are linked to acute/chronic liver diseases, viral hepatitis, and carcinogenesis.
Population
Not specified (literature review, not a clinical study)
Effective Dosage
Not available
Duration
Not applicable
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
unhealthy lifestyle-high fat diet, drug and alcohol consumption | increase | most diseases of the liver | humans | - | primarily caused | #1 |
infections and exposure to toxic substances like aflatoxin or other environmental factors | increase | most diseases of the liver | humans | - | caused | #2 |
unhealthy lifestyle-high fat diet, drug and alcohol consumption, infections and exposure to toxic substances like aflatoxin or other environmental factors | increase | the metabolism of functional cells in the liver | humans | - | cause changes in | #3 |
miRNAs and oxidative stress | increase | the multifactorial development and progression of acute and chronic liver diseases, as well as in viral hepatitis and carcinogenesis | - | - | are involved in | #4 |
miRNAs and oxidative stress | increase | numerous signaling and metabolic pathways | - | - | influencing | #5 |
expression patterns of miRNAs and antioxidants | no change | biomonitoring the course of disease | - | - | can be used for | #6 |
expression patterns of miRNAs and antioxidants | no change | possible therapeutic targets | - | - | show potential to serve as | #7 |
The liver is the central metabolic organ of mammals. In humans, most diseases of the liver are primarily caused by an unhealthy lifestyle-high fat diet, drug and alcohol consumption- or due to infections and exposure to toxic substances like aflatoxin or other environmental factors. All these noxae cause changes in the metabolism of functional cells in the liver. In this literature review we focus on the changes at the miRNA level, the formation and impact of reactive oxygen species and the crosstalk between those factors. Both, miRNAs and oxidative stress are involved in the multifactorial development and progression of acute and chronic liver diseases, as well as in viral hepatitis and carcinogenesis, by influencing numerous signaling and metabolic pathways. Furthermore, expression patterns of miRNAs and antioxidants can be used for biomonitoring the course of disease and show potential to serve as possible therapeutic targets.