Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
ginger root extract | decrease | HMG-CoA reductase levels | treated diabetic groups | - | caused a significant decrease | #1 |
ginger root extract | increase | CYP46A1 levels | treated diabetic groups | - | caused a significant increase | #2 |
ginger extract | neutral | proteins involved in cholesterol homeostasis in CNS | - | - | has a regulatory effect | #3 |
ginger extract | decrease | HMG-CoA reductase levels | - | - | significant down-regulation | #4 |
ginger extract | increase | CYP46A1 levels | - | - | significant up-regulation | #5 |
adding ginger to daily diet | neutral | - | diabetic patients | - | has useful effects | #6 |
adding ginger to daily diet | decrease | diabetes complications | diabetic patients | - | may ameliorate | #7 |
BACKGROUND: Patients with diabetes present with lipid disorders, including hypercholesterolemia, which can be a high-risk factor for atherosclerosis. Recently, increasing interest has been focused on anti-lipidemic function of herbal medicines, especially METHODS: Brains of rats were isolated from four groups: control, non-treated diabetic, and treated diabetic groups receiving 200 or 400 RESULTS: Ginger root extract caused a significant decrease in HMG-CoA reductase and an increase in CYP46A1 levels in treated diabetic groups compared to diabetic control. In comparison to diabetic group, these effects were more remarkable with 400 CONCLUSION: The findings showed that ginger extract has a regulatory effect on proteins involved in cholesterol homeostasis in CNS by a significant down- and up-regulation of HMG-CoA reductase and CYP46A1 levels, respectively. It can be suggested that adding ginger to daily diet of diabetic patients has useful effects and may ameliorate diabetes complications.