The value of nutritional supplements in treating Age-Related Macular Degeneration: a review of the literature.
Study Goal
The researchers aimed to evaluate the role of calcium in age-related macular degeneration (AMD) progression, particularly its potential detrimental effects.
Results Summary
The study found that calcium exposure may increase mechanisms of cell death and could be harmful to older individuals with AMD. The data on calcium's role in AMD progression were inconclusive but suggested potential risks.
Population
Older individuals, particularly those with AMD.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
antioxidant supplementation | decrease | AMD progression | Caucasian populations | - | show support for | #1 |
genetic guided personalized medicine | no change | - | - | - | data have not been reproducible | #2 |
antioxidant therapies | decrease | preventing AMD | Women at a higher risk of cardiovascular disease | - | may benefit | #3 |
Omega 3 fatty acid supplementation | neutral | - | - | - | has been widely supported through observational studies | #4 |
Omega 3 fatty acid supplementation | no change | disease progression | - | - | randomized controlled trials have not shown benefit | #5 |
Calcium exposure | increase | cell death | older individuals with AMD | - | has been linked to increased mechanisms in cell death | #6 |
Calcium exposure | neutral | - | older individuals with AMD | - | may be detrimental | #7 |
PURPOSE: To describe and evaluate the value of nutritional supplements in the management of age-related macular degeneration (AMD) through a review of the current literature. METHODS: An extensive literature search was performed, and key research articles exploring AREDS and AREDS-2 formulations, genetics, omega fatty acids, calcium and folic acid in high-risk women were reviewed. PubMed and Web of Science databases were used for generating articles to review. RESULTS: The AREDS and AREDS-2 trials, while difficult to validate, show support for antioxidant supplementation in reducing AMD progression in Caucasian populations. While genetic guided personalized medicine has been studied mainly with complement factor H and age-related maculopathy susceptibility 2 risk alleles, the data have not been reproducible. Women at a higher risk of cardiovascular disease may benefit from antioxidant therapies in preventing AMD. Omega 3 fatty acid supplementation has been widely supported through observational studies; however, randomized controlled trials have not shown benefit in disease progression. Calcium exposure has been linked to increased mechanisms in cell death and may be detrimental to older individuals with AMD. CONCLUSION: The data regarding nutritional supplements in preventing AMD progression are inconclusive, and therefore recommendations should be based on risk factors and demographic data.