Effects of different exercise modalities on novel hepatic steatosis indices in overweight women with type 2 diabetes.
Study Goal
The researchers aimed to examine the effects of different exercise modalities, including sprint interval training (SIT), on non-alcoholic fatty liver indices and blood glucose profiles in women with type 2 diabetes.
Results Summary
The study found that exercise training, including SIT, significantly improved non-alcoholic fatty liver indices (FLI, HSI, LAP) and blood glucose profiles (fasting blood glucose, HbA1c) in women with type 2 diabetes, with no significant differences between exercise modalities.
Population
52 women with type 2 diabetes (mean age 55.07±5.92 yrs, BMI 28.94±4.09 kg/m², HbA1c 9.41±0.82%).
Effective Dosage
Not specified (exercise modalities described as SIT and combined aerobic and resistance training).
Duration
10 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
sprint interval training (SIT) | decrease | fatty liver index (FLI) | women with type 2 diabetes (T2D) | P<0.001 | significant time interactions | #1 |
sprint interval training (SIT) | decrease | hepatic steatosis index (HSI) | women with type 2 diabetes (T2D) | P<0.001 | significant time interactions | #2 |
sprint interval training (SIT) | decrease | lipid accumulation product (LAP) | women with type 2 diabetes (T2D) | P<0.001 | significant time interactions | #3 |
combined aerobic and resistance (A+R) training | decrease | fatty liver index (FLI) | women with type 2 diabetes (T2D) | P<0.001 | significant time interactions | #4 |
combined aerobic and resistance (A+R) training | decrease | hepatic steatosis index (HSI) | women with type 2 diabetes (T2D) | P<0.001 | significant time interactions | #5 |
combined aerobic and resistance (A+R) training | decrease | lipid accumulation product (LAP) | women with type 2 diabetes (T2D) | P<0.001 | significant time interactions | #6 |
sprint interval training (SIT) | decrease | fasting blood glucose | women with type 2 diabetes (T2D) | P=0.034 | significant Time×Group interactions | #7 |
sprint interval training (SIT) | decrease | hemoglobin A1c (HbA1c) | women with type 2 diabetes (T2D) | P=0.006 | significant Time×Group interactions | #8 |
combined aerobic and resistance (A+R) training | decrease | fasting blood glucose | women with type 2 diabetes (T2D) | P=0.034 | significant Time×Group interactions | #9 |
combined aerobic and resistance (A+R) training | decrease | hemoglobin A1c (HbA1c) | women with type 2 diabetes (T2D) | P=0.006 | significant Time×Group interactions | #10 |
exercise training | improve | some indices related to hepatic steatosis | women with T2D | - | is an effective strategy to improve | #11 |
exercise training | improve | blood glucose profiles | women with T2D | - | is an effective strategy to improve | #12 |
BACKGROUND/AIMS: Fatty liver is a clinical and pathologic condition in individuals with type 2 diabetes (T2D). The purpose of this study is to examine the effects of different exercise modalities on non-alcoholic fatty liver indices (fatty liver index [FLI], lipid accumulation product [LAP], hepatic steatosis index [HSI], and Framingham Steatosis Index [FSI]) in women with T2D. METHODS: Fifty-two women with T2D and a mean age of 55.07±5.92 yrs, body mass index (BMI) 28.94±4.09 kg/m2 , and hemoglobin A1c (HbA1c) 9.41±0.82% were randomized to a sprint interval training (SIT) (n=17), combined aerobic and resistance (A+R) training (n=17), or control group (n=18) for 10 weeks. Two-way repeated analysis of variance (ANOVA) was used to find differences between groups and the effects of time and Time×Group interactions after 10 weeks on non-alcoholic fatty liver indices. After this, ANOVA models were constructed to determine the effects of group allocation and change in non-alcoholic fatty liver indices. RESULTS: There were significant time interactions for FLI (P<0.001), HSI (P<0.001), and LAP (P<0.001). Also, there were significant Time×Group interactions for fasting blood glucose (P=0.034), and HbA1c (P=0.006). CONCLUSION: Results highlight that exercise training, independent of mode of training, is an effective strategy to improve some indices related to hepatic steatosis and blood glucose profiles in women with T2D.