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Effects of different exercise modalities on novel hepatic steatosis indices in overweight women with type 2 diabetes.

Clinical and molecular hepatology
September 1, 2019
Ebrahim Banitalebi et al. (5 authors)
Journal ArticleRandomized Controlled TrialHuman StudyClinical
Study Details

Study Goal

The researchers aimed to examine the effects of different exercise modalities, including sprint interval training (SIT), on non-alcoholic fatty liver indices and blood glucose profiles in women with type 2 diabetes.

Results Summary

The study found that exercise training, including SIT, significantly improved non-alcoholic fatty liver indices (FLI, HSI, LAP) and blood glucose profiles (fasting blood glucose, HbA1c) in women with type 2 diabetes, with no significant differences between exercise modalities.

Population

52 women with type 2 diabetes (mean age 55.07±5.92 yrs, BMI 28.94±4.09 kg/m², HbA1c 9.41±0.82%).

Effective Dosage

Not specified (exercise modalities described as SIT and combined aerobic and resistance training).

Duration

10 weeks.

Interactions

None mentioned.

Extracted Claims (12)
InterventionDirectionEndpointPopulationDosageImpactClaim #
sprint interval training (SIT)
decrease
fatty liver index (FLI)
women with type 2 diabetes (T2D)
P<0.001
significant time interactions
#1
sprint interval training (SIT)
decrease
hepatic steatosis index (HSI)
women with type 2 diabetes (T2D)
P<0.001
significant time interactions
#2
sprint interval training (SIT)
decrease
lipid accumulation product (LAP)
women with type 2 diabetes (T2D)
P<0.001
significant time interactions
#3
combined aerobic and resistance (A+R) training
decrease
fatty liver index (FLI)
women with type 2 diabetes (T2D)
P<0.001
significant time interactions
#4
combined aerobic and resistance (A+R) training
decrease
hepatic steatosis index (HSI)
women with type 2 diabetes (T2D)
P<0.001
significant time interactions
#5
combined aerobic and resistance (A+R) training
decrease
lipid accumulation product (LAP)
women with type 2 diabetes (T2D)
P<0.001
significant time interactions
#6
sprint interval training (SIT)
decrease
fasting blood glucose
women with type 2 diabetes (T2D)
P=0.034
significant Time×Group interactions
#7
sprint interval training (SIT)
decrease
hemoglobin A1c (HbA1c)
women with type 2 diabetes (T2D)
P=0.006
significant Time×Group interactions
#8
combined aerobic and resistance (A+R) training
decrease
fasting blood glucose
women with type 2 diabetes (T2D)
P=0.034
significant Time×Group interactions
#9
combined aerobic and resistance (A+R) training
decrease
hemoglobin A1c (HbA1c)
women with type 2 diabetes (T2D)
P=0.006
significant Time×Group interactions
#10
exercise training
improve
some indices related to hepatic steatosis
women with T2D
-
is an effective strategy to improve
#11
exercise training
improve
blood glucose profiles
women with T2D
-
is an effective strategy to improve
#12
Abstract

BACKGROUND/AIMS: Fatty liver is a clinical and pathologic condition in individuals with type 2 diabetes (T2D). The purpose of this study is to examine the effects of different exercise modalities on non-alcoholic fatty liver indices (fatty liver index [FLI], lipid accumulation product [LAP], hepatic steatosis index [HSI], and Framingham Steatosis Index [FSI]) in women with T2D. METHODS: Fifty-two women with T2D and a mean age of 55.07±5.92 yrs, body mass index (BMI) 28.94±4.09 kg/m2 , and hemoglobin A1c (HbA1c) 9.41±0.82% were randomized to a sprint interval training (SIT) (n=17), combined aerobic and resistance (A+R) training (n=17), or control group (n=18) for 10 weeks. Two-way repeated analysis of variance (ANOVA) was used to find differences between groups and the effects of time and Time×Group interactions after 10 weeks on non-alcoholic fatty liver indices. After this, ANOVA models were constructed to determine the effects of group allocation and change in non-alcoholic fatty liver indices. RESULTS: There were significant time interactions for FLI (P<0.001), HSI (P<0.001), and LAP (P<0.001). Also, there were significant Time×Group interactions for fasting blood glucose (P=0.034), and HbA1c (P=0.006). CONCLUSION: Results highlight that exercise training, independent of mode of training, is an effective strategy to improve some indices related to hepatic steatosis and blood glucose profiles in women with T2D.

Medical Subject Headings (MeSH)
AdultAgedBlood GlucoseBody Mass IndexDiabetes Mellitus, Type 2ExerciseFemaleGlycated HemoglobinHumansMiddle AgedNon-alcoholic Fatty Liver DiseaseOverweightSingle-Blind Method
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality80/10
Citation Metrics
Total Citations14
Citations/Year2.3
Relative Citation Ratio0.75
NIH Percentile39.9%
Research Impact Scores
APT Score0.75
Weight Score2.21
Normalized Score0.70