A Review on Dietary Intervention in Obesity Associated Colon Cancer.
Study Goal
The researchers aimed to review the chemo-protective mechanisms of antioxidants-rich foods in reducing the risk of obesity-associated colorectal cancer.
Results Summary
The study identified key genes and pathways involved in obesity-associated colon cancer and suggested that dietary modification, including antioxidants-rich foods, may help in early prevention. However, the abstract does not provide specific efficacy data on antioxidants.
Population
General population, with noted higher incidence among Chinese, Indians, and Malays in Peninsular Malaysia.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
obesity | increase | colorectal cancer | - | >50% | associated with a higher risk | #1 |
dietary modification | decrease | colon cancer | - | - | alternative steps in early prevention | #2 |
components present in certain foods | decrease | cancer | - | - | may have the ability to protect against | #3 |
including antioxidants-rich foods such as vegetables and fruits in the diet | decrease | risk of obesity associated colorectal cancer | - | - | beneficial effects | #4 |
Background: Colorectal cancer (CRC) is one of the major causes of morbidity and mortality. According to National Cancer Registry, the incidence of colorectal cancer in Peninsular Malaysia increases with age. The incidence is highest among Chinese population but lower among Indians and Malays. Many reviews have suggested that obesity may be associated with a higher risk (>50%) of colorectal cancer. Methods: This study collects a comprehensive data from the literature review available from respective journals on dietary intervention and the chemo-protective mechanisms of a few natural resources in obesity -associated colon cancer based on previous and current studies. Results: In obesity-associated colon cancer, the genes of interest and pathways that are mainly involved include NFκB, P13K/Akt, and MAPK pathways, and FTO, leptin, Cyclin D, MMPs, and STAT3 genes. Dietary modification is one of the alternative steps in early prevention of colon cancer. It has been proposed that the components present in certain foods may have the ability to protect against many diseases including the prevention of cancer. Conclusion: There are many factors that lead to obesity-associated colon cancer and the mechanisms behind it is still undergoing intensive research. This review aims to scrutinize research as well as reviews that have been previously reported on obesity associated colorectal cancer and the beneficial effects of including antioxidants-rich foods such as vegetables and fruits in the diet to reduce the risk of obesity associated colorectal cancer.