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Food and Food Products on the Italian Market for Ketogenic Dietary Treatment of Neurological Diseases.

Nutrients
January 1, 1970
Alessandro Leone et al. (11 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to review the ketogenic diet's role in neurological diseases, its variants, and the development of specialized food products to improve patient quality of life.

Results Summary

The ketogenic diet is effective for glucose transporter 1 deficiency syndrome, pyruvate dehydrogenase deficiency, and refractory epilepsy, but restrictive variants have low palatability and tolerability, with side effects like gastrointestinal disorders and nutrient deficiencies. Food companies are developing specialized products to mitigate these issues.

Population

Patients with neurological diseases, including glucose transporter 1 deficiency syndrome, pyruvate dehydrogenase deficiency, and refractory epilepsy.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (15)
InterventionDirectionEndpointPopulationDosageImpactClaim #
ketogenic diet (KD)
neutral
glucose transporter 1 deficiency syndrome
-
-
is the first line intervention for
#1
ketogenic diet (KD)
neutral
pyruvate dehydrogenase deficiency
-
-
is the first line intervention for
#2
ketogenic diet (KD)
neutral
refractory epilepsy
-
-
is recommended for
#3
ketogenic diet (KD)
neutral
brain metabolism
-
-
aimed at switching
#4
ketogenic diet (KD)
decrease
carbohydrates
-
-
require the almost total exclusion, or a limited consumption of
#5
ketogenic diet (KD)
decrease
cereal-based foods
-
-
total avoidance, or a limited consumption of
#6
ketogenic diet (KD)
decrease
fruit and vegetable intake
-
-
reduction in
#7
ketogenic diet (KD)
neutral
low variability
-
-
characterized by
#8
ketogenic diet (KD)
neutral
low palatability
-
-
characterized by
#9
ketogenic diet (KD)
neutral
low tolerability
-
-
characterized by
#10
ketogenic diet (KD)
neutral
gastrointestinal disorders
-
-
characterized by side-effects, like
#11
ketogenic diet (KD)
neutral
nephrolithiasis
-
-
characterized by side-effects, like
#12
ketogenic diet (KD)
neutral
growth retardation
-
-
characterized by side-effects, like
#13
ketogenic diet (KD)
neutral
hyperlipidemia
-
-
characterized by side-effects, like
#14
ketogenic diet (KD)
neutral
mineral and vitamin deficiency
-
-
characterized by side-effects, like
#15
Abstract

The ketogenic diet (KD) is the first line intervention for glucose transporter 1 deficiency syndrome and pyruvate dehydrogenase deficiency, and is recommended for refractory epilepsy. It is a normo-caloric, high-fat, adequate-protein, and low-carbohydrate diet aimed at switching the brain metabolism from glucose dependence to the utilization of ketone bodies. Several variants of KD are currently available. Depending on the variant, KDs require the almost total exclusion, or a limited consumption of carbohydrates. Thus, there is total avoidance, or a limited consumption of cereal-based foods, and a reduction in fruit and vegetable intake. KDs, especially the more restrictive variants, are characterized by low variability, palatability, and tolerability, as well as by side-effects, like gastrointestinal disorders, nephrolithiasis, growth retardation, hyperlipidemia, and mineral and vitamin deficiency. In recent years, in an effort to improve the quality of life of patients on KDs, food companies have started to develop, and commercialize, several food products specific for such patients. This review summarizes the foods themselves, including sweeteners, and food products currently available for the ketogenic dietary treatment of neurological diseases. It describes the nutritional characteristics and gives indications for the use of the different products, taking into account their metabolic and health effects.

Medical Subject Headings (MeSH)
CommerceDiet, KetogenicFoodHumansItalyNervous System Diseases
Study Links
Quality Scores
Safety60
Efficacy80/10
Quality70/10
Citation Metrics
Total Citations16
Citations/Year2.7
Relative Citation Ratio1.10
NIH Percentile53.9%
Research Impact Scores
APT Score0.75
Weight Score1.58
Normalized Score0.70
Related Supplements
Food and Food Products on the Italian Market for Ketogenic D... | Panacea Index