Role of oxidative stress, infection and inflammation in male infertility.
Study Goal
The researchers aimed to review the role of infection and inflammation-mediated oxidative stress in male infertility and the potential treatment modalities involving antioxidants.
Results Summary
The abstract highlights that oxidative stress, caused by various infections and inflammatory conditions, is linked to sperm damage and male infertility, suggesting antioxidants may be beneficial in treatment. However, specific efficacy data on antioxidants are not detailed.
Population
Males with infertility linked to oxidative stress from infections or inflammation.
Effective Dosage
Not available
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Oxidative stress (OS) | increase | sperm damage | - | - | has been linked to | #1 |
Oxidative stress (OS) | increase | male infertility | - | - | has been linked to | #2 |
varicocele | increase | OS and inflammation | - | - | including | #3 |
tobacco usage | increase | OS and inflammation | - | - | including | #4 |
alcohol | increase | OS and inflammation | - | - | including | #5 |
obesity/metabolic syndrome | increase | OS and inflammation | - | - | including | #6 |
leukocytospermia | increase | OS and inflammation | - | - | including | #7 |
sexually transmitted disease (i.e., Neisseria gonorrhoeae, Chlamydia trachomatis, Treponema pallidum) | increase | OS and inflammation | - | - | including | #8 |
bacterial prostatitis | increase | OS and inflammation | - | - | including | #9 |
microorganism mutations | increase | more OS | - | - | leading to | #10 |
viral infections (i.e., human immunodeficiency virus, hepatitis) | increase | OS and inflammation | - | - | including | #11 |
Oxidative stress (OS), defined as an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, has been linked to sperm damage and male infertility. There are many sources of OS and inflammation including varicocele, tobacco usage, alcohol, obesity/metabolic syndrome, leukocytospermia, sexually transmitted disease (i.e., Neisseria gonorrhoeae, Chlamydia trachomatis, Treponema pallidum), bacterial prostatitis, microorganism mutations leading to more OS, and viral infections (i.e., human immunodeficiency virus, hepatitis). This review is focusing on infection and inflammation-mediated OS, the inflammatory markers underlying pathology, clinical significance in male infertility, and a brief description of the recommended treatment modalities.