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Dietary changes and cognition over 2 years within a multidomain intervention trial-The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER).

Alzheimer's & dementia : the journal of the Alzheimer's Association
March 1, 2019
Jenni Lehtisalo et al. (13 authors)
Journal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov'tHuman StudyClinical
Study Details

Study Goal

The researchers aimed to determine whether dietary changes, including dietary counseling, could improve cognitive performance in older adults at risk for cognitive impairment.

Results Summary

Adherence to a healthy diet at baseline predicted improvements in global cognition, while dietary improvement during the intervention was associated with beneficial changes in executive function, particularly in the intervention group. Long-term diet appeared more influential for global cognition than short-term dietary changes.

Population

1,260 at-risk participants aged 60-77 years.

Effective Dosage

Not specified

Duration

2 years

Interactions

None mentioned

Extracted Claims (5)
InterventionDirectionEndpointPopulationDosageImpactClaim #
adherence to healthy diet at baseline
increase
global cognition
1260 at-risk participants (60-77 years)
-
predicted improvement
#1
dietary improvement
increase
executive function
the intervention group
-
associated with beneficial changes
#2
dietary improvement
increase
executive function
groups combined
-
associated with beneficial changes
#3
dietary changes initiated during the intervention
increase
executive function
-
-
were related to changes
#4
long-term diet
increase
global cognition
-
-
appeared more influential
#5
Abstract

INTRODUCTION: Association between healthy diet and better cognition is well established, but evidence is limited to evaluate the effect of dietary changes adopted in older age. METHODS: We investigated the role of dietary changes in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) with 1260 at-risk participants (60-77 years) who were randomized to intensive multidomain intervention (including dietary counseling) or regular health advice for 2 years. Parallel process latent growth curves of adherence to dietary recommendations and cognitive performance were analyzed. RESULTS: Adherence to healthy diet at baseline predicted improvement in global cognition, regardless of intervention allocation (P = .003). Dietary improvement was associated with beneficial changes in executive function, especially in the intervention group (P = .008; P = .051 for groups combined). DISCUSSION: Dietary changes initiated during the intervention were related to changes in executive function in 2 years. Long-term diet appeared more influential for global cognition.

Medical Subject Headings (MeSH)
AgedCognitionCognitive DysfunctionDietExecutive FunctionFemaleFinlandHumansMaleMemoryMiddle AgedPatient ComplianceTreatment Outcome
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality90/10
Citation Metrics
Total Citations62
Citations/Year10.3
Relative Citation Ratio3.32
NIH Percentile87%
Research Impact Scores
APT Score0.95
Weight Score2.65
Normalized Score0.72
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