Dose-response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night-time glucose in Type 2 diabetes.
Study Goal
To explore the dose-response relationship between frequency of interrupting sedentary time with light-intensity walking breaks and basal glucose control in Type 2 diabetes.
Results Summary
Frequent interruptions of prolonged sitting with 3-minute light-intensity walking breaks every 15 minutes improved fasting glucose, reduced the dawn phenomenon, and decreased night-time glycaemic variability, but did not affect night-time mean glucose.
Population
12 people with Type 2 diabetes (age 60.0 ± 3.2 years; BMI 30.2 ± 1.4 kg/m²).
Effective Dosage
3 minutes of light-intensity walking every 15 minutes.
Duration
Not specified in the abstract.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Frequent interruptions of prolonged sitting with 3 min of light-intensity walking breaks every 15 min (Condition 3) | decrease | fasting glucose | 12 people with Type 2 diabetes | -1.0 ± 0.2 mmol/l | were lower for | #1 |
Frequent interruptions of prolonged sitting with 3 min of light-intensity walking breaks every 15 min (Condition 3) | decrease | duration of the dawn phenomenon | 12 people with Type 2 diabetes | -3.1 ± 1.3 h | were lower for | #2 |
Frequent interruptions of prolonged sitting with 3 min of light-intensity walking breaks every 15 min (Condition 3) | decrease | magnitude of the dawn phenomenon | 12 people with Type 2 diabetes | -0.6 ± 0.4 mmol/l | was reduced in | #3 |
Frequent interruptions of prolonged sitting with 3 min of light-intensity walking breaks every 15 min (Condition 3) | decrease | night-time glycaemic variability (coefficient of variation) | 12 people with Type 2 diabetes | -9.7 ± 3.9% | was reduced in | #4 |
- | no change | night-time mean glucose | 12 people with Type 2 diabetes | no significant change | There was no change in | #5 |
Frequent interruptions of prolonged sitting with 3 min of light-intensity walking breaks every 15 min | increase | fasting glucose | people with Type 2 diabetes | - | improves | #6 |
Frequent interruptions of prolonged sitting with 3 min of light-intensity walking breaks every 15 min | increase | the dawn phenomenon | people with Type 2 diabetes | - | improves | #7 |
Frequent interruptions of prolonged sitting with 3 min of light-intensity walking breaks every 15 min | increase | night-time glycaemic variability | people with Type 2 diabetes | - | improves | #8 |
AIM: To explore the dose-response between frequency of interruption of sedentary time and basal glucose (fasting glucose, the dawn phenomenon and night-time glucose) in Type 2 diabetes. METHODS: In a randomized three-treatment, two-period balanced incomplete block trial, 12 people with Type 2 diabetes (age, 60.0 ± 3.2 years; BMI, 30.2 ± 1.4 kg/m RESULTS: After treatment conditions, fasting glucose and duration of the dawn phenomenon were lower for Condition 3 (-1.0 ± 0.2 mmol/l, P < 0.02; -3.1 ± 1.3 h, P = 0.004) compared with Condition 1 (-0.1 ± 0.2 mmol/l; 1.9 ± 1.2 h). The magnitude of the dawn phenomenon was reduced in Condition 3 (-0.6 ± 0.4 mmol/l, P = 0.041) compared with Condition 2 (0.6 ± 0.3 mmol/l). Night-time glycaemic variability (coefficient of variation) was reduced in Condition 3 (-9.7 ± 3.9%) relative to Condition 2 (6.1 ± 4.8%, P < 0.03) and Condition 1 (2.5 ± 1.8%, P = 0.02). There was no change in night-time mean glucose. CONCLUSIONS: Frequent interruptions of prolonged sitting with 3 min of light-intensity walking breaks every 15 min improves fasting glucose, the dawn phenomenon and night-time glycaemic variability, and this might be a simple therapeutic intervention to improve glucose control. Clinicaltrials.gov Identifier: NCT02738996.