An oral supplementation based on myo-inositol, folic acid and liposomal magnesium may act synergistically with antibiotic therapy and can improve metabolic profile in patients affected by Hidradenitis suppurativa: our experience.
Study Goal
The researchers aimed to evaluate the effectiveness of myo-inositol (MI) supplementation combined with folic acid and liposomal magnesium in improving metabolic profile and HS symptoms in patients with impaired glucose metabolism.
Results Summary
Group A (MI supplementation) showed significant reductions in Sartorius Score and HOMA-IR compared to Group B (control), suggesting MI improved HS symptoms and insulin resistance. The results were statistically significant, indicating clinical relevance.
Population
20 subjects with Hidradenitis suppurativa (HS) and impaired glucose metabolism.
Effective Dosage
MI 2000 mg daily, liposomal magnesium, and folic acid.
Duration
6 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
oral supplementation based on myo-inositol (MI), folic acid and liposomal magnesium associated to topical antibiotic therapy (clindamycin gel 1%), systemic antibiotic therapy (clindamycin 300 mg b.i.d. and rifampicin 600 mg daily for 6 weeks) and a normocaloric diet | decrease | Sartorius Score | subjects with HS and an impaired glucose metabolism (Group A) | from 38.3±7.75 to 27.3±13.53 | showed an average reduction | #1 |
topical and systemic antibiotic therapy associated to a normocaloric diet | decrease | Sartorius Score | subjects with HS and an impaired glucose metabolism (Group B) | from 38.4±7.88 to 31.1±8.02 | there was a reduction | #2 |
oral supplementation based on myo-inositol (MI), folic acid and liposomal magnesium associated to topical antibiotic therapy (clindamycin gel 1%), systemic antibiotic therapy (clindamycin 300 mg b.i.d. and rifampicin 600 mg daily for 6 weeks) and a normocaloric diet | decrease | Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) | subjects with HS and an impaired glucose metabolism (Group A) | from 2.43±0.35 to 2.1±0.31 | was significantly reduced | #3 |
topical and systemic antibiotic therapy associated to a normocaloric diet | no change | Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) | subjects with HS and an impaired glucose metabolism (Group B) | from 2.51±0.65 to 2.40±0.67 | did not significantly decrease | #4 |
BACKGROUND: Over recent years, the link between obesity, metabolic syndrome and Hidradenitis suppurativa (HS) has been explored. It has been demonstrated that HS patients have a high prevalence of the metabolic syndrome and an increased frequency of insulin resistance. The objective of our study is to estimate the effectiveness of an oral supplementation based on myo-inositol (MI), folic acid and liposomal magnesium (Levigon METHODS: Twenty subjects with HS and an impaired glucose metabolism were enrolled. Group A: 10 subjects received for 6 months MI 2000 mg, liposomal magnesium and folic acid associated to topical antibiotic therapy (clindamycin gel 1%), systemic antibiotic therapy (clindamycin 300 mg b.i.d. and rifampicin 600 mg daily for 6 weeks) and a normocaloric diet group B: 10 subjects received topical and systemic antibiotic therapy associated to a normocaloric diet for 6 months. RESULTS: After 6 months group A patients showed an average reduction of Sartorius Score from 38.3±7.75 to 27.3±13.53 (P value <0.04) while in the control group there was a reduction of the Sartorius from 38.4±7.88 to 31.1±8.02 (P value =0.55). Moreover in group A Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was significantly reduced from 2.43±0.35 to 2.1±0.31 (P<0.01) whereas in group B HOMA-IR did not significantly decrease (2.51±0.65 at T0 at 2.40±0.67 at T1). CONCLUSIONS: Our study underlines the importance of the evaluation of metabolic profile in patients with HS. Moreover, it suggests that the supplementation of MI, folic acid and liposomal magnesium in HS can improve the efficacy of concomitant therapies and the metabolic profile.