Melatonin reduces two-cell block via nonreceptor pathway in mice.
Journal of cellular biochemistry
November 1, 2018
Feifei Shi et al. (5 authors)
Journal ArticleResearch Support, Non-U.S. Gov'tAnimal Study
Extracted Claims (24)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin supplementation | increase | blastocyst formation rate | porcine embryos | from 30.2% to 41.8% | significantly increased | #1 |
melatonin supplementation | increase | total cell number per blastocyst | porcine embryos | from 48.6 to 58.3 | significantly increased | #2 |
melatonin supplementation | decrease | apoptosis index | porcine embryos | from 6.8% to 4.1% | significantly decreased | #3 |
melatonin supplementation | increase | mitochondrial membrane potential | porcine embryos | - | significantly increased | #4 |
melatonin supplementation | increase | ATP content | porcine embryos | - | significantly increased | #5 |
melatonin supplementation | decrease | reactive oxygen species levels | porcine embryos | - | significantly decreased | #6 |
melatonin supplementation | increase | glutathione levels | porcine embryos | - | significantly increased | #7 |
melatonin supplementation | increase | expression of antioxidant genes | porcine embryos | - | significantly increased | #8 |
melatonin supplementation | increase | expression of anti-apoptotic genes | porcine embryos | - | significantly increased | #9 |
melatonin supplementation | decrease | expression of pro-apoptotic genes | porcine embryos | - | significantly decreased | #10 |
melatonin supplementation | increase | expression of genes related to mitochondrial biogenesis | porcine embryos | - | significantly increased | #11 |
melatonin supplementation | increase | expression of genes related to mitochondrial dynamics | porcine embryos | - | significantly increased | #12 |
melatonin supplementation | increase | expression of genes related to mitochondrial function | porcine embryos | - | significantly increased | #13 |
melatonin supplementation | increase | expression of genes related to mitochondrial quality control | porcine embryos | - | significantly increased | #14 |
melatonin supplementation | increase | expression of genes related to mitochondrial fusion | porcine embryos | - | significantly increased | #15 |
melatonin supplementation | decrease | expression of genes related to mitochondrial fission | porcine embryos | - | significantly decreased | #16 |
melatonin supplementation | increase | expression of genes related to mitochondrial autophagy | porcine embryos | - | significantly increased | #17 |
melatonin supplementation | increase | expression of genes related to mitochondrial biogenesis | porcine embryos | - | significantly increased | #18 |
melatonin supplementation | increase | expression of genes related to mitochondrial dynamics | porcine embryos | - | significantly increased | #19 |
melatonin supplementation | increase | expression of genes related to mitochondrial function | porcine embryos | - | significantly increased | #20 |
melatonin supplementation | increase | expression of genes related to mitochondrial quality control | porcine embryos | - | significantly increased | #21 |
melatonin supplementation | increase | expression of genes related to mitochondrial fusion | porcine embryos | - | significantly increased | #22 |
melatonin supplementation | decrease | expression of genes related to mitochondrial fission | porcine embryos | - | significantly decreased | #23 |
melatonin supplementation | increase | expression of genes related to mitochondrial autophagy | porcine embryos | - | significantly increased | #24 |
Abstract
Embryo development block seriously limits the success of in vitro embryo production and assisted reproductive technology. Although numerous researchers have explored this problem, it remains to be solved. In this study, we found that melatonin supplementation at 10
Medical Subject Headings (MeSH)
AnimalsAntioxidantsFemaleGlutathione PeroxidaseMatrix Metalloproteinase 14Matrix Metalloproteinase 15MelatoninMiceSuperoxide DismutaseTryptamines
Study Links
PubMed ID30074260
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