Vitamin D: And its role in breast cancer.
Study Goal
The researchers aimed to clarify the role of vitamin D in the onset and progression of breast cancer and to suggest new research directions for vitamin D supplementation in breast cancer patients.
Results Summary
The abstract highlights vitamin D's potential extraskeletal actions, linking deficiency to increased risks of various diseases, including breast cancer. It discusses mechanisms like apoptosis induction, cell differentiation, and anti-inflammatory effects, suggesting a protective role against cancer progression.
Population
Patients with breast cancer (specific population not detailed in the abstract).
Effective Dosage
Not mentioned
Duration
Not mentioned
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D | increase | infection | - | - | linked vitamin D deficiency to an increased risk of | #1 |
vitamin D | increase | diabetes mellitus types 1 and 2 | - | - | linked vitamin D deficiency to an increased risk of | #2 |
vitamin D | increase | cardiovascular disease | - | - | linked vitamin D deficiency to an increased risk of | #3 |
vitamin D | increase | obesity | - | - | linked vitamin D deficiency to an increased risk of | #4 |
vitamin D | increase | asthma | - | - | linked vitamin D deficiency to an increased risk of | #5 |
vitamin D | increase | inflammatory bowel disease | - | - | linked vitamin D deficiency to an increased risk of | #6 |
vitamin D | increase | colon cancer | - | - | linked vitamin D deficiency to an increased risk of | #7 |
vitamin D | increase | breast cancer | - | - | linked vitamin D deficiency to an increased risk of | #8 |
vitamin D | increase | prostate cancer | - | - | linked vitamin D deficiency to an increased risk of | #9 |
vitamin D | increase | ovarian cancer | - | - | linked vitamin D deficiency to an increased risk of | #10 |
vitamin D | increase | some neurological diseases | - | - | linked vitamin D deficiency to an increased risk of | #11 |
vitamin D | increase | induction of apoptosis | - | - | influences the natural history of cancer through | #12 |
vitamin D | increase | stimulation of cell differentiation | - | - | influences the natural history of cancer through | #13 |
vitamin D | decrease | anti-inflammatory effects | - | - | influences the natural history of cancer through | #14 |
vitamin D | decrease | antiproliferative effects | - | - | influences the natural history of cancer through | #15 |
vitamin D | decrease | inhibition of angiogenesis | - | - | influences the natural history of cancer through | #16 |
vitamin D | decrease | inhibition of invasion | - | - | influences the natural history of cancer through | #17 |
vitamin D | decrease | inhibition of metastasis | - | - | influences the natural history of cancer through | #18 |
Vitamin D is a fat soluble vitamin that plays a role in calcium and phosphorus homeostasis. Recently, extensive research on its extraskeletal actions has linked vitamin D deficiency to an increased risk of infection, diabetes mellitus types 1 and 2, cardiovascular disease, obesity, asthma, inflammatory bowel disease, colon, breast, prostate and ovarian cancer and some neurological diseases. There are various mechanisms by which vitamin D influences the natural history of cancer. These include the role of vitamin D in the induction of apoptosis, stimulation of cell differentiation, anti-inflammatory and antiproliferative effects and inhibition of angiogenesis, invasion and metastasis. The aim of this review is to clarify the true role of vitamin D in the onset of breast cancer and evolution of the disease after treatment. A further aim is to suggest new research directions to identify indications and requirements for vitamin D supplementation in patients with breast cancer.