The Effect of Zinc Gluconate Supplementation on Symptoms and Tongue Epithelium Regeneration in Non-psoriatic Patients with Migratory Glossitis.
Study Goal
The researchers aimed to evaluate the effectiveness of zinc gluconate in treating symptomatic migratory glossitis (MG) compared to dietary zinc alone.
Results Summary
Zinc gluconate supplementation significantly reduced the size of red atrophied areas and symptom intensity in MG patients, with 85.7% showing papillae regeneration. The control group showed minimal improvement.
Population
28 non-psoriatic patients with symptomatic migratory glossitis.
Effective Dosage
20 mg/day of chelated zinc gluconate.
Duration
One month.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
20 mg/day of chelated zinc gluconate for one month, and a diet rich in zinc | decrease | mean value of the red atrophy area width and length | non-psoriatic patients with symptomatic migratory glossitis (MG) in the test group | - | displayed some significant reduction | #1 |
diet rich in zinc only | no change | size of red patches | non-psoriatic patients with symptomatic migratory glossitis (MG) in the control group | - | no significant changes | #2 |
20 mg/day of chelated zinc gluconate for one month, and a diet rich in zinc | decrease | intensity of subjective symptoms | non-psoriatic patients with symptomatic migratory glossitis (MG) in the test group | - | significantly decreased | #3 |
20 mg/day of chelated zinc gluconate for one month, and a diet rich in zinc | increase | filiform papillae | non-psoriatic patients with symptomatic migratory glossitis (MG) in the test group | 85.7% of cases | partially or completely regenerated | #4 |
diet rich in zinc only | increase | filiform papillae | non-psoriatic patients with symptomatic migratory glossitis (MG) in the control group | 23.1% of the controls | partially or completely regenerated | #5 |
20 mg/day of chelated zinc gluconate for one month, and a diet rich in zinc | no change | red patches with raised keratotic rims healing spontaneously and reappearing in constantly changing patterns | patients supplemented with zinc | - | not observed | #6 |
20 mg/day of chelated zinc gluconate for one month, and a diet rich in zinc | decrease | new atrophy areas | patients supplemented with zinc | - | occurred in only one case | #7 |
The aim of this study was to evaluate zinc gluconate as a treatment option in patients with symptomatic migratory glossitis (MG). Using simple random sampling, 28 non-psoriatic patients with symptomatic MG were divided into a test and control group. The test group took 20 mg/day of chelated zinc gluconate for one month, and was put on a diet rich in zinc. The control group was only put on a diet rich in zinc. Changes in the size of red atrophied areas (width and length) and the intensity of symptoms were evaluated as primary and secondary outcomes, respectively, at baseline, after therapy, and one month later. In the test group, the mean value of the red atrophy area width and length displayed some significant reduction as a primary outcome. There were no significant changes in the size of red patches in the control group. Secondary outcome showed that the intensity of subjective symptoms in the test group significantly decreased (P=0.042) compared with controls. The filiform papillae had partially or completely regenerated in 85.7% of cases in the test group and in 23.1% of the controls (P=0.001). Red patches with raised keratotic rims may have healed spontaneously and reappeared in constantly changing patterns that are typical for MG. This phenomenon was not observed in patients supplemented with zinc, and new atrophy areas occurred in only one case. Low-dose zinc gluconate.