Prevalence of celiac disease among pediatric patients with cryptogenic cirrhosis and effect of gluten-free-diet.
Study Goal
The researchers aimed to determine the prevalence of celiac disease (CD) in children with cryptogenic cirrhosis and assess the effects of a gluten-free diet (GFD) on liver function in these patients.
Results Summary
The study found that 13.1% of children with cryptogenic cirrhosis had CD. After 6 months of GFD, the CD group showed improvements in hemoglobin levels, liver function tests, and Child-Pugh scores.
Population
Children under 18 years old with cryptogenic cirrhosis.
Effective Dosage
Not specified
Duration
6 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
gluten-free-diet (GFD) | increase | hemoglobin levels | CLD with CD group | - | improvement | #1 |
gluten-free-diet (GFD) | increase | liver function tests | CLD with CD group | - | improvement | #2 |
gluten-free-diet (GFD) | increase | Child-Pugh score | CLD with CD group | - | improvement | #3 |
gluten-free-diet (GFD) | increase | hepatic functions | CD patients with cirrhosis | - | improve | #4 |
BACKGROUND: Liver involvement in celiac disease (CD) is classified into autoimmune and cryptogenic. The association between CD and autoimmune liver diseases like autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis is well-established; however, the data on patients with cryptogenic cirrhosis, particularly from India, are scanty. So we did this study to find the prevalence of CD in patients with cryptogenic cirrhosis. METHODS: This was a prospective observational study, involving children of less than 18 years old attending Pediatric and Gastroenterology clinic with a diagnosis of cryptogenic cirrhosis. The patients were evaluated for CD and divided into two groups: chronic liver disease (CLD) with CD, and CLD without CD. Both the groups were followed up for 6 months. CLD with CD group was treated with gluten-free-diet (GFD) and CLD without CD group was followed up without any specific intervention except standard care of CLD. RESULTS: Out of 84 patients, 11 (13.1%) were diagnosed as CLD with CD. There was an improvement in hemoglobin levels, liver function tests, and Child-Pugh score after initiation of GFD in CLD with CD group. CONCLUSION: The prevalence of CD in cryptogenic cirrhosis was 13.1%. Screening for CD is recommended for cryptogenic cirrhosis. Hepatic functions improve with a GFD in CD patients with cirrhosis.