Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases.
Study Goal
The researchers aimed to determine whether melatonin could rectify altered phosphorylation/dephosphorylation rates in neurodegenerative diseases by influencing phosphoprotein phosphatases.
Results Summary
The study found that melatonin may counteract mechanisms leading to neurodegeneration, such as proteinopathy, mitochondrial dysfunction, and oxidative stress, by potentially rectifying phosphorylation/dephosphorylation imbalances. It suggests melatonin offers protective activity toward these enzymes, possibly through direct interaction.
Population
Not specified (general focus on neurodegenerative diseases).
Effective Dosage
Not provided.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | decrease | neurodegenerative scenario | - | - | counteracting the events that lead to a neurodegenerative scenario | #1 |
melatonin | decrease | altered phosphorylation/dephosphorylation rate | patients with some neurodegenerative diseases | - | rectify the altered phosphorylation/dephosphorylation rate | #2 |
melatonin | increase | activity of phosphoprotein phosphatases | - | - | influencing the activity of phosphoprotein phosphatases | #3 |
Melatonin is an endogenous hormone produced by the pineal gland as well as many other tissues and organs. The natural decline in melatonin levels with ageing contributes significantly to the development of neurodegenerative disorders. Neurodegenerative diseases share common mechanisms of toxicity such as proteinopathy, mitochondrial dysfunction, metal dyshomeostasis, oxidative stress, neuroinflammation and an imbalance in the phosphorylation/dephosphorylation ratio. Several reports have proved the usefulness of melatonin in counteracting the events that lead to a neurodegenerative scenario. In this review, we have focused on the fact that melatonin could rectify the altered phosphorylation/dephosphorylation rate found in some neurodegenerative diseases by influencing the activity of phosphoprotein phosphatases. We analyse whether melatonin offers any protective activity towards these enzymes through a direct interaction. LINKED ARTICLES: This article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc.