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Effect of protein intake beyond habitual intakes following resistance training on cardiometabolic risk disease parameters in pre-conditioned older women.

Experimental gerontology
September 1, 2018
Rodrigo R Fernandes et al. (11 authors)
Journal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov'tHuman StudyClinical
Study Details

Study Goal

The researchers aimed to analyze the effects of higher protein intake combined with resistance training on cardiometabolic risk parameters in older women.

Results Summary

The high-protein group showed greater improvements in lean soft tissue, total cholesterol/HDL ratio, and volume of load compared to the placebo group. Both groups improved in HDL, LDL, triglycerides, total cholesterol, LDL/HDL ratio, and CRP, but without significant differences between them.

Population

Pre-conditioned older women

Effective Dosage

35 g of protein (whey) after training sessions

Duration

12 weeks

Interactions

None mentioned

Extracted Claims (13)
InterventionDirectionEndpointPopulationDosageImpactClaim #
higher protein (HP) intake associated with resistance training (RT)
increase
lean soft tissue (LST)
pre-conditioned older women
+3.8% vs +2.0%
presented greater improvements
#1
higher protein (HP) intake associated with resistance training (RT)
decrease
total cholesterol/high density lipoprotein ratio (TC/HDL)
pre-conditioned older women
-11.8% vs -2.9%
presented greater improvements
#2
higher protein (HP) intake associated with resistance training (RT)
increase
volume of load (VL)
pre-conditioned older women
45.4% vs 35.4%
presented greater improvements
#3
higher protein (HP) intake associated with resistance training (RT)
increase
HDL
pre-conditioned older women
+6.7% vs +6.3%
improved
#4
higher protein (HP) intake associated with resistance training (RT)
decrease
LDL
pre-conditioned older women
-6.8% vs +0.9%
improved
#5
higher protein (HP) intake associated with resistance training (RT)
decrease
Triglycerides (TGC)
pre-conditioned older women
-2.0% vs -1.2%
improved
#6
higher protein (HP) intake associated with resistance training (RT)
decrease
total cholesterol (TC)
pre-conditioned older women
-2.8% vs +0.5%
improved
#7
higher protein (HP) intake associated with resistance training (RT)
decrease
low density lipoprotein/HDL ratio (LDL/HDL)
pre-conditioned older women
-11.5 vs -6.9%
improved
#8
higher protein (HP) intake associated with resistance training (RT)
decrease
C-reactive protein (CRP)
pre-conditioned older women
-8.6% vs -11.5%
improved
#9
higher protein (HP) intake associated with resistance training (RT)
no change
waist circumference
pre-conditioned older women
-
No effect was found
#10
Increased dietary protein intake, achieved by whey protein supplementation, when associated with RT
increase
LST
pre-conditioned older women
-
promotes greater gains
#11
Increased dietary protein intake, achieved by whey protein supplementation, when associated with RT
increase
VL
pre-conditioned older women
-
promotes greater gains
#12
Increased dietary protein intake, achieved by whey protein supplementation, when associated with RT
decrease
TC/HDL ratio
pre-conditioned older women
-
promotes a reduction
#13
Abstract

OBJECTIVE: The aim of this study was to analyze the effects of higher protein (HP) intake associated with resistance training (RT) on parameters of cardiometabolic risk disease (CMR). METHODS: A randomized, double-blind and placebo-controlled design was conducted. Thirty-two pre-conditioned older women were randomized in two groups to receive 35 g of protein (high protein group - HP) or 35 g of placebo (low protein group - LP) after training sessions. The RT program was carried out over 12 weeks, 3 days per week and 3 sets of 8-12 repetitions. Body composition (whole-body dual-energy X-ray absorptiometry), blood samples, anthropometric measurements and dietary intake were performed at pre- and post-intervention. RESULTS: There was a significant group-by-time interaction (P < 0.05) for lean soft tissue (LST), total cholesterol/high density lipoprotein ratio (TC/HDL) and volume of load (VL), in which HP group presented greater improvements when compared to LP group (LST: +3.8% vs +2.0%; TC/HDL: -11.8% vs -2.9%; VL: 45.4% vs 35.4%). A time effect was found for HDL, LDL, Triglycerides (TGC), total cholesterol (TC), low density lipoprotein/HDL ratio (LDL/HDL) and C-reactive protein (CRP) (HDL: +6.7% vs +6.3%; LDL: -6.8% vs +0.9%; TGC: -2.0% vs -1.2%; TC: -2.8% vs +0.5%; LDL/HDL: -11.5 vs -6.9%; CRP: -8.6% vs -11.5%) in which both groups improved their scores without statistical differences between them. No effect was found for waist circumference. CONCLUSION: Increased dietary protein intake, achieved by whey protein supplementation, when associated with RT promotes greater gains on LST and VL, and a reduction on TC/HDL ratio in pre-conditioned older women.

Medical Subject Headings (MeSH)
Absorptiometry, PhotonAgedBiomarkersBody CompositionC-Reactive ProteinCardiovascular DiseasesCholesterol, HDLCholesterol, LDLDiet, High-ProteinDietary SupplementsDouble-Blind MethodFemaleHumansMetabolic SyndromeMetabolomeMiddle AgedResistance TrainingTriglyceridesWaist CircumferenceWhey Proteins
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality90/10
Citation Metrics
Total Citations20
Citations/Year2.9
Relative Citation Ratio1.24
NIH Percentile58.1%
Research Impact Scores
APT Score0.75
Weight Score2.29
Normalized Score0.72
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