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Dietary therapy for eosinophilic esophagitis.

The Journal of allergy and clinical immunology
July 1, 2018
Javier Molina-Infante et al. (2 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the efficacy of dairy elimination diets in managing eosinophilic esophagitis, comparing different dietary restriction approaches.

Results Summary

Dairy was identified as one of the most common food triggers for eosinophilic esophagitis in both children and adults. A 2-food elimination diet (dairy and gluten-containing cereals) showed a 43% efficacy rate, while a 4-food elimination diet (including dairy) achieved 54% efficacy in adults and 64% in children.

Population

Children and adults from the United States, Spain, and Australia with eosinophilic esophagitis.

Effective Dosage

Not specified

Duration

6 weeks for empiric elimination diets

Interactions

None mentioned

Extracted Claims (9)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Elemental diets (exclusive feeding with amino acid-based formulas)
increase
efficacy rates
-
best
have consistently shown the best efficacy rates
#1
empiric 6-food elimination diets (withdrawing milk, wheat, egg, soy, nuts, and fish/seafood for 6 weeks)
increase
efficacy rates
-
best
have consistently shown the best efficacy rates
#2
a 2-food elimination diet (dairy and gluten-containing cereals)
increase
efficacy rates
-
43%
have lately developed with good efficacy rates
#3
a 4-food elimination diet (dairy, gluten-containing cereals, egg, and legumes)
increase
efficacy rates
adults
54%
have lately developed with good efficacy rates
#4
a 4-food elimination diet (dairy, gluten-containing cereals, egg, and legumes)
increase
efficacy rates
children
64%
have lately developed with good efficacy rates
#5
A step-up approach (2-4-6)
increase
recognition of responders
-
majority
might result in prompt recognition of a majority of responders with few food triggers
#6
A step-up approach (2-4-6)
decrease
number of endoscopies
-
-
reducing the number of endoscopies
#7
A step-up approach (2-4-6)
decrease
costs
-
-
reducing the costs
#8
A step-up approach (2-4-6)
decrease
diagnostic process
-
-
shortening the diagnostic process
#9
Abstract

Eosinophilic esophagitis is a chronic, immune-mediated esophageal disease triggered predominantly, but not exclusively, by food antigens. Presently, available food allergy tests are suboptimal to predict food triggers for eosinophilic esophagitis, especially in adults. Elemental diets (exclusive feeding with amino acid-based formulas) and empiric 6-food elimination diets (withdrawing milk, wheat, egg, soy, nuts, and fish/seafood for 6 weeks) have consistently shown the best efficacy rates. However, their high level of restriction and need for multiple endoscopies have hampered their implementation in clinical practice. Currently, milk, wheat/gluten, and egg are the most common food triggers in children and adults from the United States, Spain, and Australia. Hence less restrictive empiric schemes, such as a 4-food elimination diet (dairy, gluten-containing cereals, egg, and legumes) or a 2-food elimination diet (dairy and gluten-containing cereals) have been lately developed with good efficacy rates (2-food elimination diet, 43%; 4-food elimination diet in adults, 54%; and 4-food elimination diet in children, 64%). A step-up approach (2-4-6) might result in prompt recognition of a majority of responders with few food triggers, reducing the number of endoscopies and costs and shortening the diagnostic process. Standardization of food reintroduction, novel food allergy testing, and studies evaluating a milk elimination diet in children and the long-term outcomes of dietary interventions are warranted.

Medical Subject Headings (MeSH)
Eosinophilic EsophagitisFood HypersensitivityHumans
Study Links
Quality Scores
SafetyNot Assessed
Efficacy54/10
Quality75/10
Citation Metrics
Total Citations43
Citations/Year6.1
Relative Citation Ratio2.37
NIH Percentile79.4%
Research Impact Scores
APT Score0.75
Weight Score2.16
Normalized Score0.57
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