The effect of CBT and its modifications for relapse prevention in major depressive disorder: a systematic review and meta-analysis.
Study Goal
The researchers aimed to evaluate the efficacy of cognitive behavioral therapy (CBT) and its modifications, including mindfulness-based cognitive therapy (MBCT), in reducing relapse risk for major depressive disorder (MDD) patients in remission.
Results Summary
CBT was found to be more efficacious than control in reducing relapse risk within the first 12 months (HR:0.50). MBCT's effectiveness was moderated by the number of prior depressive episodes, showing efficacy primarily for patients with 3 or more previous episodes.
Population
MDD patients in remission.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Cognitive behavioral therapy (CBT) | decrease | risk of developing a new episode of depression | MDD patients in remission | HR:0.50, 95%CI:0.35-0.72 | was more efficacious than control in reducing the risk | #1 |
Mindfulness-based cognitive therapy (MBCT) | decrease | risk of developing a new episode of depression | MDD patients in remission | HR:0.69, 95%CI:0.56-0.86 | was more efficacious than control in reducing the risk | #2 |
Cognitive behavioral therapy (CBT) | decrease | risk of relapse | MDD patients in remission | - | might reduce risk | #3 |
Mindfulness-based cognitive therapy (MBCT) | decrease | relapse | MDD patients with 3 or more previous episodes | - | might only be effective | #4 |
BACKGROUND: The risk of relapse in major depressive disorder (MDD) is associated with high worldwide disease burden. Cognitive behavioral therapy (CBT) and its modifications might be effective in relapse prevention. The aim of this review was to evaluate the efficacy of these treatments for reducing relapse of MDD. METHODS: The retrieval was performed in the databases of MEDLINE via Pubmed, EMBASE and PsycINFO via OVID, The Cochrane Library and four Chinese databases. Clinical trials registry platforms and references of relevant articles were retrieved as well. Hazard ratio (HR) and corresponding 95% confidence interval (CI) were used to pool evidences. RESULTS: A total of 16 eligible trials involving 1945 participants were included. In the first 12 months, CBT was more efficacious than control in reducing the risk of developing a new episode of depression for MDD patients in remission (HR:0.50, 95%CI:0.35-0.72, I CONCLUSION: The use of CBT for MDD patients in remission might reduce risk of relapse. Besides, the effect of MBCT was moderated by number of prior episodes and MBCT might only be effective for MDD patients with 3 or more previous episodes. Further exploration for the influence of previous psychological intervention is required.