Resistance training during a 12-week protein supplemented VLCD treatment enhances weight-loss outcomes in obese patients.
Study Goal
The researchers were attempting to determine the efficacy of resistance training in enhancing body composition, metabolic, and functional outcomes for obese patients undergoing a 12-week medically supervised hypocaloric treatment.
Results Summary
The study found that resistance training preserved lean mass without compromising overall weight- or fat-loss, improved resting metabolism, and enhanced muscular function compared to the control group.
Population
Morbidly obese men and women
Effective Dosage
Not specified
Duration
12 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
12-week proprietary very low calorie diet (VLCD) treatment (Optifast) | decrease | total body mass (TBM) | morbidly obese patients | -19.4 ± 2.3 kg | exhibited a significant loss | #1 |
12-week proprietary very low calorie diet (VLCD) treatment (Optifast) with resistance training | decrease | total body mass (TBM) | morbidly obese patients | -15.8 ± 1.5 kg | exhibited a significant loss | #2 |
12-week proprietary very low calorie diet (VLCD) treatment (Optifast) | decrease | fat mass (FM) | morbidly obese patients | -14.7 ± 1.8 kg | exhibited a significant loss | #3 |
12-week proprietary very low calorie diet (VLCD) treatment (Optifast) with resistance training | decrease | fat mass (FM) | morbidly obese patients | -15.1 ± 2.1 kg | exhibited a significant loss | #4 |
12-week proprietary very low calorie diet (VLCD) treatment (Optifast) | decrease | lean mass (LM) | morbidly obese patients | 4.6 ± 0.8 kg | lost | #5 |
12-week proprietary very low calorie diet (VLCD) treatment (Optifast) with resistance training | no change | lean mass (LM) | morbidly obese patients | - | demonstrated no changes | #6 |
12-week proprietary very low calorie diet (VLCD) treatment (Optifast) | decrease | REE | morbidly obese patients | 328.6 ± 72.7 kcal/day (-14.3 ± 2.4%) | demonstrated a decrease | #7 |
12-week proprietary very low calorie diet (VLCD) treatment (Optifast) with resistance training | decrease | REE | morbidly obese patients | 4.6 ± 1.6% | exhibited a non-significant decrease | #8 |
resistance training | increase | all measures of contractile function and strength | morbidly obese patients | - | demonstrated greater improvements | #9 |
resistance training | increase | serum free fatty acids | morbidly obese patients | - | exhibited greater | #10 |
resistance training | increase | glycerol | morbidly obese patients | - | exhibited greater | #11 |
resistance training | increase | β-hydroxybutyrate | morbidly obese patients | - | exhibited greater | #12 |
resistance training | no change | lean mass (LM) | morbidly obese men and women undergoing a protein supplemented VLCD | - | was advantageous for weight-loss composition by preservation | #13 |
BACKGROUND: This investigation evaluated the efficacy by which resistance training enhances body composition, metabolic, and functional outcomes for obese patients undergoing a 12-week medically supervised hypocaloric treatment. METHODS: This was a single-blind, randomized, parallel-group prospective trial. Morbidly obese patients were prescribed a 12-week proprietary very low calorie diet (VLCD) treatment (Optifast RESULTS: Both groups exhibited a significant loss of total body mass (TBM) (CON: -19.4 ± 2.3 kg, p = 0.0009 vs. RT: -15.8 ± 1.5 kg, p = 0.0002) and fat mass (FM) (CON: -14.7 ± 1.8 kg, p = 0.0002 vs. RT: -15.1 ± 2.1 kg, p = 0.0002) with no group differences. CON lost 4.6 ± 0.8 kg (p = 0.004) of lean mass (LM) while RT demonstrated no changes. Group differences were found for the relative proportion of total weight-loss due to FM-loss (CON: 75.6 ± 3.4% vs. RT: 96.0 ± 6.0%, p = 0.03) and LM-loss (CON: 24.4 ± 3.2% vs. RT: 4.0 ± 6.5%, p = 0.03). CON demonstrated a 328.6 ± 72.7 kcal/day (-14.3 ± 2.4%) (p = 0.02) decrease in REE while RT exhibited a non-significant decrease of 4.6 ± 1.6% (p = 0.78). RT demonstrated greater improvements in all measures of contractile function and strength when compared to CON (p < 0.05). At post-treatment, RT exhibited greater serum free fatty acids (p = 0.01), glycerol (p = 0.003), and β-hydroxybutyrate (p = 0.005) than CON. CONCLUSION: Resistance training was advantageous for weight-loss composition by preservation of LM without compromising overall weight- or fat-loss in morbidly obese men and women undergoing a protein supplemented VLCD. These changes accompanied positive adaptations for resting metabolism and muscular function.