Magnesium-zinc-calcium-vitamin D co-supplementation improves glycemic control and markers of cardiometabolic risk in gestational diabetes: a randomized, double-blind, placebo-controlled trial.
Study Goal
The researchers aimed to determine the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and cardiometabolic risk markers in patients with gestational diabetes mellitus (GDM).
Results Summary
The co-supplementation significantly improved glycemic control (reduced fasting glucose, insulin levels, and insulin resistance) and lowered triglycerides and very-low-density-cholesterol concentrations compared to placebo.
Population
Patients with GDM, aged 18-40 years.
Effective Dosage
Not specified
Duration
6 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | fasting plasma glucose | patients with GDM | -0.37 ± 0.09 vs. +0.01 ± 0.09 mmol/L | resulted in significant reductions in | #1 |
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | serum insulin levels | patients with GDM | -21.0 ± 4.8 vs. +7.2 ± 4.8 pmol/L | resulted in significant reductions in | #2 |
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | homeostatic model of assessment for insulin resistance | patients with GDM | -1.0 ± 1.1 vs. +0.3 ± 1.3 | resulted in significant reductions in | #3 |
magnesium-zinc-calcium-vitamin D co-supplementation | increase | quantitative insulin sensitivity check index | patients with GDM | +0.02 ± 0.03 vs. -0.002 ± 0.03 | resulted in a significant increase in | #4 |
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | serum triglycerides | patients with GDM | -0.25 ± 0.10 vs. +0.34 ± 0.10 mmol/L | significantly decreased | #5 |
magnesium-zinc-calcium-vitamin D co-supplementation | decrease | very-low-density-cholesterol concentrations | patients with GDM | -0.11 ± 0.04 vs. +0.15 ± 0.04 mmol/L | significantly decreased | #6 |
magnesium-zinc-calcium-vitamin D co-supplementation | neutral | glycemic control | patients with GDM | - | had beneficial effects on | #7 |
magnesium-zinc-calcium-vitamin D co-supplementation | neutral | few markers of cardiometabolic risk | patients with GDM | - | had beneficial effects on | #8 |
To the best our knowledge, data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardiometabolic risk in gestational diabetes mellitus (GDM) are scarce. The purpose of this study was to establish the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardiometabolic risk of GDM patients. Sixty patients with GDM, aged 18-40 years, were randomized into 2 groups to intake either magnesium-zinc-calcium-vitamin D co-supplements or placebo (n = 30 each group) for 6 weeks in a randomized, double-blind, placebo-controlled trial. Fasting blood samples were taken at baseline and week 6 to quantify related markers. After the 6-week intervention, compared with the placebo, magnesium-zinc-calcium-vitamin D co-supplementation resulted in significant reductions in fasting plasma glucose (-0.37 ± 0.09 vs. +0.01 ± 0.09 mmol/L, P = 0.003), serum insulin levels (-21.0 ± 4.8 vs. +7.2 ± 4.8 pmol/L, P < 0.001), homeostatic model of assessment for insulin resistance (-1.0 ± 1.1 vs. +0.3 ± 1.3, P < 0.001), and a significant increase in quantitative insulin sensitivity check index (+0.02 ± 0.03 vs. -0.002 ± 0.03, P = 0.003). In addition, magnesium-zinc-calcium-vitamin D co-supplementation significantly decreased serum triglycerides (-0.25 ± 0.10 vs. +0.34 ± 0.10 mmol/L, P = 0.001) and very-low-density-cholesterol concentrations (-0.11 ± 0.04 vs. +0.15 ± 0.04 mmol/L, P = 0.001) compared with the placebo. Overall, the results of this study demonstrated that magnesium-zinc-calcium-vitamin D co-supplementation for 6 weeks among patients with GDM had beneficial effects on glycemic control and few markers of cardiometabolic risk.