Vitamin D supplementation for the prevention of vitamin D deficiency after bariatric surgery: a systematic review and meta-analysis.
Study Goal
The researchers aimed to evaluate the efficacy of vitamin D supplementation in preventing postoperative vitamin D deficiency in patients who underwent bariatric surgery.
Results Summary
Vitamin D supplementation significantly improved 1-year vitamin D depletion and 25-OHD levels, with a daily dosage of more than 800 IU being particularly effective. The benefits were more pronounced in randomized controlled trials (RCTs) compared to non-RCTs.
Population
Patients who had undergone bariatric surgery (1,285 participants across 12 studies).
Effective Dosage
More than 800 IU daily was effective; less than 800 IU daily was not.
Duration
1 year
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D supplementation | decrease | 1-year Vitamin D depletion | patients who had undergone bariatric surgery | - | was associated with significant improvements | #1 |
Vitamin D supplementation | increase | 1-year 25-OHD level | patients who had undergone bariatric surgery | - | was associated with significant improvements | #2 |
A daily supplement of more than 800 IU vitamin D | decrease | prevalence of 1-year Vitamin D depletion | patients who had undergone bariatric surgery | - | significantly reduced | #3 |
dosage of less than 800 IU | no change | prevalence of 1-year Vitamin D depletion | patients who had undergone bariatric surgery | - | did not | #4 |
Vitamin D supplementation | decrease | 1-year Vitamin D depletion | randomized controlled trials (RCTs) | - | Significant decrease in prevalence | #5 |
Vitamin D supplementation | no change | 1-year Vitamin D depletion | non-RCTs | - | not | #6 |
Vitamin D supplementation | increase | 1-year 25-OHD level | studies irrespective of the study design and dosage | - | significant elevation | #7 |
Vitamin D supplementation with a daily dosage of more than 800 IU | decrease | postoperative vitamin D deficiency | patients who had undergone bariatric surgery | - | is effective in preventing | #8 |
Vitamin D supplementation with a daily dosage of more than 800 IU | increase | the 25-OHD level | patients who had undergone bariatric surgery | - | improving | #9 |
OBJECTIVE: To evaluate the efficacy of vitamin D supplementation on the prevention of postoperative vitamin D deficiency. METHODS: PubMed, Embase, Web of Science, and Cochrane library were searched. Prospective studies evaluating the effects of vitamin D supplementation in patients who had undergone bariatric surgery were included. Meta-regression was performed to explore heterogeneity, and assess the relationship between dosage of vitamin D supplementation, study design, and prevalence of vitamin D depletion. RESULTS: Twelve studies enrolling 1285 patients met the inclusion criteria, and were included. Vitamin D supplementation was associated with significant improvements in 1-year Vitamin D depletion and 1-year 25-OHD level. A daily supplement of more than 800 IU vitamin D significantly reduced the prevalence of 1-year Vitamin D depletion, but the dosage of less than 800 IU did not. Significant decrease in prevalence of 1-year Vitamin D depletion was observed in randomized controlled trials (RCTs), but not in non-RCTs. For the 1-year 25-OHD level, significant elevation was found in the studies irrespective of the study design and dosage of vitamin D supplementation. Meta-regression showed that there was significant relationship between vitamin D depletion and study design, but not between vitamin D depletion and the dosage of vitamin D supplementation. CONCLUSION: Vitamin D supplementation with a daily dosage of more than 800 IU is effective in preventing postoperative vitamin D deficiency and improving the 25-OHD level. However, the results should be interpreted cautiously since there was significant heterogeneity among the studies.