Antiobesity potential of Piperonal: promising modulation of body composition, lipid profiles and obesogenic marker expression in HFD-induced obese rats.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
High-fat diet (HFD) | increase | body weight | rats | - | substantially induced | #1 |
High-fat diet (HFD) | increase | fat% | rats | - | substantially induced | #2 |
High-fat diet (HFD) | increase | adipocyte size | rats | - | substantially induced | #3 |
High-fat diet (HFD) | increase | circulatory and tissue lipid profiles | rats | - | substantially induced | #4 |
High-fat diet (HFD) | increase | plasma levels of insulin | rats | - | elevated | #5 |
High-fat diet (HFD) | increase | insulin resistance | rats | - | elevated | #6 |
High-fat diet (HFD) | increase | leptin | rats | - | elevated | #7 |
High-fat diet (HFD) | decrease | adiponectin | rats | - | decreased | #8 |
High-fat diet (HFD) | decrease | BMC | rats | - | decreased | #9 |
High-fat diet (HFD) | decrease | BMD | rats | - | decreased | #10 |
High-fat diet (HFD) | increase | PPAR-γ | HFD-fed rats | - | increased expression | #11 |
High-fat diet (HFD) | increase | FAS | HFD-fed rats | - | increased expression | #12 |
High-fat diet (HFD) | increase | Fab-4 | HFD-fed rats | - | increased expression | #13 |
High-fat diet (HFD) | increase | UCP-2 | HFD-fed rats | - | increased expression | #14 |
High-fat diet (HFD) | increase | SREBP-1c | HFD-fed rats | - | increased expression | #15 |
High-fat diet (HFD) | increase | ACC | HFD-fed rats | - | increased expression | #16 |
High-fat diet (HFD) | increase | TNF-α | HFD-fed rats | - | increased expression | #17 |
piperonal (20, 30 and 40 mg/kg b.wt) | decrease | HFD-induced alterations | HFD-fed rats | - | considerably and dose-dependently attenuated | #18 |
piperonal (40 mg/kg b.wt) | decrease | HFD-induced alterations | HFD-fed rats | - | maximum therapeutic activity | #19 |
Piperonal | decrease | HFD-induced body weight | - | - | significantly attenuated | #20 |
Piperonal | decrease | HFD-induced biochemical changes | - | - | significantly attenuated | #21 |
BACKGROUND: Black pepper or METHODS: Piperonal, an active constituent of RESULTS: HFD substantially induced body weight, fat%, adipocyte size, circulatory and tissue lipid profiles. It elevated the plasma levels of insulin, insulin resistance and leptin but decreased the levels of adiponectin, BMC and BMD. Increased expression of PPAR-γ, FAS, Fab-4, UCP-2, SREBP-1c, ACC, and TNF-α was noticed in HFD-fed rats. However, supplementation of piperonal (20, 30 and 40 mg/kg b.wt) for 42 days considerably and dose-dependently attenuated the HFD-induced alterations, with the maximum therapeutic activity being noticed at 40 mg/kg b.wt. CONCLUSIONS: Piperonal significantly attenuated HFD-induced body weight and biochemical changes through modulation of key lipid metabolizing and obesogenic genes. Our findings demonstrate the efficacy of piperonal as a potent antiobesity agent, provide scientific evidence for its traditional use and suggest the possible mechanism of action.