Effect of whey protein supplementation on levels of endocannabinoids and some of metabolic risk factors in obese women on a weight-loss diet: a study protocol for a randomized controlled trial.
Study Goal
The researchers aimed to determine the effects of whey protein supplementation on endocannabinoids, metabolic risk factors, and body composition in obese women on a weight-loss diet.
Results Summary
The study did not report specific results in the abstract, but it intended to explore the benefits of whey protein alongside a weight-loss diet on metabolic and health markers.
Population
60 premenopausal obese women
Effective Dosage
Not specified
Duration
2 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
dietary long chain PUFA | neutral | circulating endocannabinoids concentrations | - | - | effects on | #1 |
whey protein supplementation | neutral | levels of endocannabinoids | 60 premenopausal obese women on a weight-loss diet | - | determine the effect on | #2 |
whey protein supplementation | neutral | glycemic profile | 60 premenopausal obese women on a weight-loss diet | - | determine the effect on | #3 |
whey protein supplementation | neutral | lipid profile | 60 premenopausal obese women on a weight-loss diet | - | determine the effect on | #4 |
whey protein supplementation | neutral | inflammatory factors | 60 premenopausal obese women on a weight-loss diet | - | determine the effect on | #5 |
whey protein supplementation | neutral | adipocytokines | 60 premenopausal obese women on a weight-loss diet | - | determine the effect on | #6 |
whey protein supplementation | neutral | body composition | 60 premenopausal obese women on a weight-loss diet | - | determine the effect on | #7 |
weight loss diet | neutral | health and metabolic risk factors | - | - | illustrate the other benefits on | #8 |
simultaneous weight loss diet and whey protein supplementation | neutral | these variables | - | - | determine the effects on | #9 |
BACKGROUND: Besides the effects of dietary long chain PUFA on circulating endocannabinoids concentrations, the impact of other nutrients on these system is not known and, whether changes in plasma endocannabinoids levels correlated with changes in body composition and biochemical metabolic risk factors in obese individuals, however, still remains to be characterized. METHODS: We will conduct a 2 months' open label, parallel-group, randomized controlled trial to determine the effect of whey protein supplementation on levels of endocannabinoids, glycemic and lipid profile, inflammatory factors, adipocytokines and body composition in 60 premenopausal obese women on a weight-loss diet. CONCLUSION: Due to strong relationship between endocannabinoids level and insulin resistance and obesity, in this trial, we will illustrate the other benefits of weight loss diet on health and metabolic risk factors. Also for the first, the effects of simultaneous weight loss diet and whey protein supplementation on these variables will be determined. TRIAL REGISTRATION: Iranian Registry of Clinical Trials IRCT2017021410181N8 .