Recent advances in pharmacological, hormonal, and nutritional intervention for sarcopenia.
Study Goal
The researchers aimed to evaluate the effectiveness of resistance training combined with amino acid-containing supplements in preventing sarcopenia.
Results Summary
Resistance training combined with amino acid-containing supplements was identified as the gold standard for preventing sarcopenia, while protein (amino acid) supplementation alone did not influence sarcopenic symptoms. Other potential strategies like myostatin inhibition, mild caloric restriction, and supplementation with ursolic acid and ghrelin were also discussed but require further research.
Population
Older adults at risk of or experiencing sarcopenia (age-related muscle loss).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Resistance training combined with amino acid-containing supplements | decrease | sarcopenia | - | - | is the gold standard to prevent | #1 |
Supplementation with proteins (amino acids) only | no change | sarcopenic symptoms | - | - | did not influence | #2 |
A myostatin-inhibiting strategy | decrease | sarcopenia | humans | - | is the most important candidate to prevent | #3 |
Milder caloric restriction (CR, 15-25%) | decrease | age-related muscle atrophy | humans | - | would also be effective for | #4 |
Supplementation with ursolic acid and ghrelin | decrease | sarcopenia | - | - | is an intriguing candidate to combat | #5 |
Sarcopenia, the age-related loss of skeletal muscle mass, is characterized by a deterioration of muscle quantity and quality leading to a gradual slowing of movement, a decline in strength and power, increased risk of fall-related injury, and often frailty. This review focuses on the recent advances of pharmacological, hormonal, and nutritional approaches for attenuating sarcopenia. The article is composed of the data reported in many basic and some clinical studies for mammalian muscles. Resistance training combined with amino acid-containing supplements is the gold standard to prevent sarcopenia. Supplementation with proteins (amino acids) only did not influence sarcopenic symptoms. A myostatin-inhibiting strategy is the most important candidate to prevent sarcopenia in humans. Milder caloric restriction (CR, 15-25%) would also be effective for age-related muscle atrophy in humans. Supplementation with ursolic acid and ghrelin is an intriguing candidate to combat sarcopenia, although further systematic and fundamental research is needed on this treatment.