Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
500 mg A-GPC | increase | serum free choline | healthy, college aged males | 132% | elevated | #1 |
250 mg A-GPC | increase | serum free choline | healthy, college aged males | 59% | elevated | #2 |
500 mg A-GPC | decrease | serum TSH | healthy, college aged males | - | significantly depressed | #3 |
500 mg A-GPC | no change | IMTP performance | healthy, college aged males | - | No differences were noted | #4 |
500 mg A-GPC | no change | UBIST performance | healthy, college aged males | - | No differences were noted | #5 |
500 mg A-GPC | no change | PVT performance | healthy, college aged males | - | No differences were noted | #6 |
250 mg A-GPC | no change | IMTP performance | healthy, college aged males | - | No differences were noted | #7 |
250 mg A-GPC | no change | UBIST performance | healthy, college aged males | - | No differences were noted | #8 |
250 mg A-GPC | no change | PVT performance | healthy, college aged males | - | No differences were noted | #9 |
200 mg Caffeine | no change | IMTP performance | healthy, college aged males | - | No differences were noted | #10 |
200 mg Caffeine | no change | UBIST performance | healthy, college aged males | - | No differences were noted | #11 |
200 mg Caffeine | no change | PVT performance | healthy, college aged males | - | No differences were noted | #12 |
Placebo | no change | IMTP performance | healthy, college aged males | - | No differences were noted | #13 |
Placebo | no change | UBIST performance | healthy, college aged males | - | No differences were noted | #14 |
Placebo | no change | PVT performance | healthy, college aged males | - | No differences were noted | #15 |
BACKGROUND: Recent studies have suggested that alpha glycerylphosphorylcholine (A-GPC) may be an effective ergogenic aid. The present study was designed to assess the efficacy of two doses of A-GPC in comparison to placebo and caffeine for increasing countermovement jump performance, isometric strength, and psychomotor function. METHODS: Forty-eight healthy, college aged males volunteered for the present study and underwent baseline assessment of countermovement jump (CMJ), isometric mid thigh pull (IMTP), upper body isometric strength test (UBIST), and psychomotor vigilance (PVT). Following this assessment participants were randomly assigned to groups consisting of 500 mg A-GPC, 250 mg A-GPC, 200 mg Caffeine or Placebo taken daily. Blood samples were collected 1 h and 2 h post initial dose to quantify serum free choline and thyroid stimulating hormone then subjects returned after 7 days of supplementation to repeat CMJ, IMTP, UBIST and PVT. RESULTS: No differences were noted between groups for IMTP, UBIST or PVT performance. Serum free choline was found to be elevated in the two A-GPC groups as compared to placebo (132% and 59% respectively). Serum TSH was found to be significantly depressed in the 500 mg A-GPC group compared to other treatments ( CONCLUSIONS: Based upon this evidence, and previous evidence regarding A-GPC, it should be considered as an emerging ergogenic supplement.