Ketogenic diet in endocrine disorders: Current perspectives.
Study Goal
The researchers aimed to summarize the evidence and clinical application of the ketogenic diet (KD) in diabetes, obesity, and other endocrine disorders, including its benefits and an Indian vegetarian variant.
Results Summary
The study found that KD improves glycemic control in diabetics, promotes significant weight loss, benefits cardiac ischemic preconditioning, enhances oxygenation in respiratory failure, and positively impacts polycystic ovarian syndrome. Ketones are proposed as a super-metabolic fuel, and KD is considered suitable for "diabesity."
Population
Patients with diabetes, obesity, and other endocrine disorders, including an Indian vegetarian variant.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Ketogenic diet (KD) | decrease | epilepsy | patients with refractory epilepsy | - | long known for antiepileptic effects | #1 |
Ketogenic diet (KD) | increase | cardiac ischemic preconditioning | - | - | has beneficial effects on | #2 |
Ketogenic diet (KD) | increase | oxygenation | patients with respiratory failure | - | improves | #3 |
Ketogenic diet (KD) | increase | glycemic control | diabetics | - | improves | #4 |
Ketogenic diet (KD) | decrease | weight loss | - | - | is associated with significant | #5 |
Ketogenic diet (KD) | increase | polycystic ovarian syndrome | - | - | has a beneficial impact on | #6 |
Multivitamin supplementations | neutral | - | - | - | are recommended with | #7 |
Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diabetes, obesity, and other endocrine disorders. KD is usually animal protein based. An empiric vegetarian Indian variant of KD has been provided keeping in mind the Indian food habits. KD has beneficial effects on cardiac ischemic preconditioning, improves oxygenation in patients with respiratory failure, improves glycemic control in diabetics, is associated with significant weight loss, and has a beneficial impact on polycystic ovarian syndrome. Multivitamin supplementations are recommended with KD. Recently, ketones are being proposed as super-metabolic fuel; and KD is currently regarded as apt dietary therapy for "diabesity."