Glucose effectiveness, but not insulin sensitivity, is improved after short-term interval training in individuals with type 2 diabetes mellitus: a controlled, randomised, crossover trial.
Study Goal
The researchers aimed to determine whether interval walking training (IWT) or continuous walking training (CWT) improves glucose effectiveness (S) in individuals with type 2 diabetes.
Results Summary
IWT improved glucose effectiveness (S) after two weeks, while CWT did not show significant improvement. Thirteen participants completed the study, and the results suggest IWT may be more effective than CWT for glucose management in type 2 diabetes.
Population
Fourteen participants with type 2 diabetes, excluding those on exogenous insulin, smokers, pregnant individuals, or those with contraindications to physical activity.
Effective Dosage
Ten supervised treadmill walking sessions, each lasting 60 minutes, over 2 weeks (IWT: 3 min slow walking alternating with 3 min fast walking; CWT: moderate walking speed).
Duration
2 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
interval walking training (IWT) | increase | glucose effectiveness (S_G) | participants with type 2 diabetes | - | improved | #1 |
continuous walking training (CWT) | no change | glucose effectiveness (S_G) | participants with type 2 diabetes | - | no effect | #2 |
AIMS/HYPOTHESIS: The role of glucose effectiveness (S METHODS: Fourteen participants with type 2 diabetes underwent three trials (IWT, CWT and no training) in a crossover study. Exclusion criteria were exogenous insulin treatment, smoking, pregnancy, contraindications to structured physical activity and participation in recurrent training (>90 min/week). The trials were performed in a randomised order (computerised-generated randomisation). IWT and CWT consisted of ten supervised treadmill walking sessions, each lasting 60 min, over 2 weeks. IWT was performed as repeated cycles of 3 min slow walking and 3 min fast walking (aiming for 54% and 89% of [Formula: see text], respectively, which was measured during the last minute of each interval), and CWT was performed aiming for a moderate walking speed (73% of [Formula: see text]). A two-step (pancreatic and hyperinsulinaemic) hyperglycaemic clamp was implemented before and after each trial. All data were collected in a hospitalised setting. Neither participants nor assessors were blinded to the trial interventions. RESULTS: Thirteen individuals completed all procedures and were included in the analyses. IWT improved S CONCLUSIONS/INTERPRETATION: Two weeks of IWT, but not CWT, improves S TRIAL REGISTRATION: ClinicalTrials.gov NCT02320526 FUNDING: CFAS is supported by a grant from TrygFonden. During the study period, the Centre of Inflammation and Metabolism (CIM) was supported by a grant from the Danish National Research Foundation (DNRF55). The study was further supported by grants from Diabetesforeningen, Augustinusfonden and Krista og Viggo Petersens Fond. CIM/CFAS is a member of DD2-the Danish Center for Strategic Research in Type 2 Diabetes (the Danish Council for Strategic Research, grant no. 09-067009 and 09-075724).