Ketones and Human Performance.
Study Goal
The researchers aimed to evaluate the potential performance benefits and risks of a ketogenic diet and ketone supplements, particularly for Special Operations Forces (SOF).
Results Summary
The study found that most human studies on ketogenic diets yielded equivocal, null, or negative results regarding performance benefits, with no clear evidence supporting its efficacy for SOF. Ketone supplements' benefits were noted as largely anecdotal.
Population
Special Operations Forces (SOF) and general human performance studies.
Effective Dosage
Not specified
Duration
Several days to weeks for ketogenic diet; rapid induction for ketone supplements (exact duration not specified).
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
fasting for longer than 72 hours | increase | ketosis | - | - | can be achieved | #1 |
very low-carbohydrate, high-fat diet (ketogenic diet) for several days to weeks | increase | ketosis | - | - | can be achieved | #2 |
ketone supplements | increase | ketosis | - | - | purportedly induce | #3 |
chronic ketosis without caloric restriction | no change | submaximal exercise capability | - | - | could preserve | #4 |
chronic ketosis without caloric restriction | increase | glycogen | - | - | sparing | #5 |
chronic ketosis without caloric restriction | increase | limited carbohydrate stores | - | - | conserving | #6 |
ketogenic diet | increase | positive results | human studies on performance | few | have yielded | #7 |
ketogenic diet | no change | equivocal or null results | most studies on performance | most | have yielded | #8 |
ketogenic diet | decrease | negative results | a few studies on performance | a few | have yielded | #9 |
ketogenic diet and/or a ketone supplement | no change | performance benefits | Special Operations Forces (SOF) | - | do not appear confer | #10 |
Everyone is seeking nutritional strategies that might benefit performance. One approach receiving much attention is ketones, or ketosis. Ketones are very simple compounds made of hydrogen, carbon, and oxygen, and ketosis is a metabolic state whereby the body uses predominantly ketones. Ketosis can be achieved by fasting for longer than 72 hours or by following a very lowcarbohydrate, high-fat diet (ketogenic diet) for several days to weeks. Alternatively, ketone supplements purportedly induce ketosis rapidly and do not require strict adherence to any specific type of diet; however, much of the touted benefits are anecdotal. A potential role for ketosis as a performance enhancer was first introduced in 1983 with the idea that chronic ketosis without caloric restriction could preserve submaximal exercise capability by sparing glycogen or conserving the limited carbohydrate stores. Few human studies on the effects of a ketogenic diet on performance have yielded positive results, and most studies have yielded equivocal or null results, and a few negative results. Many questions about ketones relevant to Special Operations Forces (SOF) remain unanswered. At present, a ketogenic diet and/or a ketone supplement do not appear confer performance benefits for SOF. Instead, Operators should engage with their unit dietitian to develop individualized nutritional strategies based on unique mission requirements. The authors review the concept of a ketogenic diet, describe some potential benefits and risks of ketosis, review the performance literature and how to measure ketone status, and then summarize the landscape in 2017.