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Ketones and Human Performance.

Journal of special operations medicine : a peer reviewed journal for SOF medical professionals
January 1, 2017
Jonathan M Scott et al. (2 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the potential performance benefits and risks of a ketogenic diet and ketone supplements, particularly for Special Operations Forces (SOF).

Results Summary

The study found that most human studies on ketogenic diets yielded equivocal, null, or negative results regarding performance benefits, with no clear evidence supporting its efficacy for SOF. Ketone supplements' benefits were noted as largely anecdotal.

Population

Special Operations Forces (SOF) and general human performance studies.

Effective Dosage

Not specified

Duration

Several days to weeks for ketogenic diet; rapid induction for ketone supplements (exact duration not specified).

Interactions

None mentioned

Extracted Claims (10)
InterventionDirectionEndpointPopulationDosageImpactClaim #
fasting for longer than 72 hours
increase
ketosis
-
-
can be achieved
#1
very low-carbohydrate, high-fat diet (ketogenic diet) for several days to weeks
increase
ketosis
-
-
can be achieved
#2
ketone supplements
increase
ketosis
-
-
purportedly induce
#3
chronic ketosis without caloric restriction
no change
submaximal exercise capability
-
-
could preserve
#4
chronic ketosis without caloric restriction
increase
glycogen
-
-
sparing
#5
chronic ketosis without caloric restriction
increase
limited carbohydrate stores
-
-
conserving
#6
ketogenic diet
increase
positive results
human studies on performance
few
have yielded
#7
ketogenic diet
no change
equivocal or null results
most studies on performance
most
have yielded
#8
ketogenic diet
decrease
negative results
a few studies on performance
a few
have yielded
#9
ketogenic diet and/or a ketone supplement
no change
performance benefits
Special Operations Forces (SOF)
-
do not appear confer
#10
Abstract

Everyone is seeking nutritional strategies that might benefit performance. One approach receiving much attention is ketones, or ketosis. Ketones are very simple compounds made of hydrogen, carbon, and oxygen, and ketosis is a metabolic state whereby the body uses predominantly ketones. Ketosis can be achieved by fasting for longer than 72 hours or by following a very lowcarbohydrate, high-fat diet (ketogenic diet) for several days to weeks. Alternatively, ketone supplements purportedly induce ketosis rapidly and do not require strict adherence to any specific type of diet; however, much of the touted benefits are anecdotal. A potential role for ketosis as a performance enhancer was first introduced in 1983 with the idea that chronic ketosis without caloric restriction could preserve submaximal exercise capability by sparing glycogen or conserving the limited carbohydrate stores. Few human studies on the effects of a ketogenic diet on performance have yielded positive results, and most studies have yielded equivocal or null results, and a few negative results. Many questions about ketones relevant to Special Operations Forces (SOF) remain unanswered. At present, a ketogenic diet and/or a ketone supplement do not appear confer performance benefits for SOF. Instead, Operators should engage with their unit dietitian to develop individualized nutritional strategies based on unique mission requirements. The authors review the concept of a ketogenic diet, describe some potential benefits and risks of ketosis, review the performance literature and how to measure ketone status, and then summarize the landscape in 2017.

Medical Subject Headings (MeSH)
Athletic PerformanceDiet, KetogenicDietary SupplementsExercise ToleranceFastingHumansKetonesKetosisTask Performance and Analysis
Study Links
Quality Scores
SafetyNot Assessed
Efficacy30/10
Quality60/10
Citation Metrics
Total Citations9
Citations/Year1.1
Relative Citation Ratio0.40
NIH Percentile21.4%
Research Impact Scores
APT Score0.50
Weight Score1.59
Normalized Score0.44
Related Supplements
Ketones and Human Performance. | Panacea Index