Effects of Dietary Approach to Stop Hypertension diet on androgens, antioxidant status and body composition in overweight and obese women with polycystic ovary syndrome: a randomised controlled trial.
Study Goal
The researchers aimed to determine the effects of the DASH diet, which includes low-fat dairy, on reproductive hormones, antioxidant status, and anthropometric indices in overweight and obese women with PCOS.
Results Summary
The DASH diet, which included low-fat dairy, was associated with significant improvements in weight loss, BMI, fat mass, serum androstenedione reduction, antioxidant status, and SHBG levels compared to the control diet.
Population
Overweight and obese women with polycystic ovary syndrome (PCOS).
Effective Dosage
Not specified (dietary inclusion of low-fat dairy as part of the DASH diet).
Duration
3 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Dietary Approaches to Stop Hypertension (DASH) diet | decrease | weight | overweight and obese PCOS women | -5.78 (1.91) kg versus -4.34 (2.87) kg | significant reduction | #1 |
Dietary Approaches to Stop Hypertension (DASH) diet | decrease | body mass index (BMI) | overweight and obese PCOS women | -2.29 (0.15) kg m | significant reduction | #2 |
Dietary Approaches to Stop Hypertension (DASH) diet | decrease | weight loss | overweight and obese PCOS women | - | improve | #3 |
Dietary Approaches to Stop Hypertension (DASH) diet | decrease | BMI | overweight and obese PCOS women | - | improve | #4 |
Dietary Approaches to Stop Hypertension (DASH) diet | decrease | fat mass | overweight and obese PCOS women | - | improve | #5 |
Dietary Approaches to Stop Hypertension (DASH) diet | decrease | serum androstenedione | overweight and obese PCOS women | - | significant reduction | #6 |
Dietary Approaches to Stop Hypertension (DASH) diet | increase | antioxidant status | overweight and obese PCOS women | - | significant increase | #7 |
Dietary Approaches to Stop Hypertension (DASH) diet | increase | SHBG | overweight and obese PCOS women | - | significant increase | #8 |
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrine disease in reproductive age women. The present study aimed to determine the effects of Dietary Approaches to Stop Hypertension (DASH) diet on reproductive hormones, plasma total antioxidant status and anthropometric indices in overweight and obese PCOS women. METHODS: In this randomised controlled clinical trial, 60 women with PCOS were randomly assigned to one of two diets with energy restriction: the DASH diet and a control diet. The DASH and control diets consisted of 50-55% carbohydrate, 15-20% protein and 25-30% total fat. The DASH diet was designed to be rich in vegetables, fruits, whole grains and low-fat dairy products, as well as low in saturated fats, cholesterol, refined grains and sweets. In the present study, the anthropometric indices, body composition, total testosterone, androstenedione, sex hormone binding globulin (SHBG), free androgen index and 2,2'-diphenyl-1-picryylhydrazyl (DPPH) scavenging activity were measured before and after 3 months. RESULTS: The consumption of DASH diet compared to the control diet was associated with a significant reduction in weight [-5.78 (1.91) kg versus -4.34 (2.87) kg, P = 0.032], body mass index (BMI) [-2.29 (0.15) kg m CONCLUSIONS: The DASH diet could improve weight loss, BMI and fat mass. Furthermore, it could result in a significant reduction in serum androstenedione and a significant increase in antioxidant status and SHBG.