Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity.
Study Goal
The researchers aimed to determine if differences in micronutrient intake, including Vitamin A, between high and low AGE diets could explain variations in insulin sensitivity.
Results Summary
The high AGE diet contained significantly higher levels of Vitamin A (retinol equivalents) compared to the low AGE diet, but these changes did not correlate with insulin sensitivity, suggesting Vitamin A intake differences did not explain the observed changes in insulin sensitivity.
Population
Participants in a dietary intervention study (specific demographics not detailed in the abstract).
Effective Dosage
High AGE diet: 806.3 ± 223.5 μg RE/day; Low AGE diet: 649.1 ± 235.8 μg RE/day.
Duration
Each diet was consumed for 2 weeks, with a 4-week washout period in-between.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
isoenergetic low advanced glycation end products (AGEs) diet | increase | insulin sensitivity | - | - | improved | #1 |
high AGE diet | increase | retinol equivalents (RE) | - | 478.9 + 151.3 μg/day versus 329.0 + 170.0 μg/day | contained greater levels | #2 |
high AGE diet | increase | vitamin A | - | 806.3 + 223.5 (μg RE)/day versus 649.1 + 235.8 (μg RE)/day | contained greater levels | #3 |
high AGE diet | increase | thiamine | - | 2.3 + 0.6 mg/day versus 1.6 + 0.4 mg/day | contained greater levels | #4 |
changes in polyunsaturated fat | no change | insulin sensitivity | - | - | did not correlate | #5 |
changes in retinol | no change | insulin sensitivity | - | - | did not correlate | #6 |
changes in vitamin A | no change | insulin sensitivity | - | - | did not correlate | #7 |
changes in thiamine | no change | insulin sensitivity | - | - | did not correlate | #8 |
We have previously shown that an isoenergetic low advanced glycation end products (AGEs) diet matched for macronutrient content improved insulin sensitivity compared to high AGE diet. Here, we evaluated the differences in micronutrient intake of these two dietary patterns and if they could explain differences in insulin sensitivity. Participants consumed the intervention diets each for 2 weeks with 4 weeks of habitual dietary intake (washout) in-between. Dietary analysis revealed that the high AGE diet contained greater levels of retinol equivalents (RE) (478.9 + 151.3 μg/day versus 329.0 + 170.0 μg/day; p < .006), vitamin A (806.3 + 223.5 (μg RE)/day versus 649.1 + 235.8 (μg RE)/day; p < .05) and thiamine (2.3 + 0.6 mg/day versus 1.6 + 0.4 mg/day; p = .014) compared to the low AGE diet. The changes in polyunsaturated fat, retinol, vitamin A and thiamine did not correlate with changes in insulin sensitivity (all p > .1) therefore are unlikely to explain observed changes in insulin sensitivity. (clinicaltrials.gov:NCT00422253).