Association Between Adherence to the Mediterranean Diet at Midlife and Healthy Aging in a Cohort of French Adults.
Study Goal
The researchers aimed to investigate the association between adherence to the Mediterranean diet at midlife and healthy aging, defined by multiple health dimensions.
Results Summary
Higher adherence to the Mediterranean diet was associated with increased odds of healthy aging, with potential mediation by metabolic health-related factors.
Population
3,012 French adults aged 45-60 years at baseline, initially free of major chronic diseases.
Effective Dosage
Not specified (adherence assessed via dietary records).
Duration
Follow-up from 1994-1995 to 2007-2009 (~13-15 years).
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
higher adherence to the Mediterranean diet at midlife | increase | healthy aging (HA) | participants of the French SU.VI.MAX study aged 45-60 years at baseline and initially free of major chronic diseases | 1.36 [1.12; 1.65] | were associated with higher odds of | #1 |
higher scores on the Literature-based Adherence Score to the Mediterranean Diet (LAMD) | increase | healthy aging (HA) | participants of the French SU.VI.MAX study aged 45-60 years at baseline and initially free of major chronic diseases | 1.36 [1.12; 1.65] | were associated with higher odds of | #2 |
high adherence to the Mediterranean diet at midlife | increase | good overall health during aging | - | - | suggest a favorable role for maintaining | #3 |
BACKGROUND: The Mediterranean diet has been suggested as a key element for the prevention of age-related chronic diseases. However, very few studies have examined its relation with multidimensional concepts of healthy aging (HA). Our objective was thus to investigate the association between adherence to the Mediterranean diet at midlife and HA. METHODS: We analyzed data from 3,012 participants of the French SUpplémentation en Vitamines et Minéraux AntioXydants (SU.VI.MAX) study aged 45-60 years at baseline (1994-1995) and initially free of major chronic diseases, with available data on HA status in 2007-2009. We defined HA as not developing major chronic disease (cancer, cardiovascular disease, or diabetes), good physical and cognitive functioning (evaluated by validated, standardized tests), independence in instrumental activities of daily living, no depressive symptoms, good social functioning, good self-perceived health, and no function-limiting pain. An index assessing adherence to the Mediterranean diet, the Literature-based Adherence Score to the Mediterranean Diet (LAMD) was calculated using baseline data from repeated 24-hour dietary records. RESULTS: In 2007-2009, 38% of participants met the HA criteria. Multivariable logistic regression revealed that higher scores on the LAMD (ORTertile 3 vs Tertile 1: 1.36 [1.12; 1.65]) were associated with higher odds of HA. Supplementary analyses using structural equation modeling revealed a potential mediation of the observed associations by metabolic health-related factors. CONCLUSIONS: Our results suggest a favorable role of a high adherence to the Mediterranean diet at midlife for maintaining good overall health during aging.