Mediterranean Diet Supplemented With Coenzyme Q10 Modulates the Postprandial Metabolism of Advanced Glycation End Products in Elderly Men and Women.
Study Goal
The researchers aimed to determine whether supplementing a Mediterranean diet with Coenzyme Q10 (CoQ) provided additional benefits in reducing oxidative stress and AGEs levels compared to the diet alone.
Results Summary
The study found that a Mediterranean diet reduced AGEs levels and improved redox-state parameters, and these benefits were further enhanced by CoQ supplementation, particularly in the postprandial state.
Population
Twenty participants aged ≥65 (10 men and 10 women).
Effective Dosage
Not specified.
Duration
4 weeks per diet period (Med diet, Med + CoQ, SFA diet) in a crossover design.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Mediterranean (Med) diet | decrease | oxidative stress | healthy elderly people | - | reduces | #1 |
Mediterranean (Med) diet | decrease | serum AGEs levels | healthy elderly people | - | reduces | #2 |
Mediterranean (Med) diet | decrease | gene expression related to AGEs metabolism | healthy elderly people | - | reduces | #3 |
Med diet | neutral | redox-state parameters | participants aged ≥ 65 | - | modulated | #4 |
Med diet | decrease | AGEs levels | participants aged ≥ 65 | - | reducing | #5 |
Med diet | increase | AGER1 mRNA levels | participants aged ≥ 65 | - | increasing | #6 |
Med diet | increase | GloxI mRNA levels | participants aged ≥ 65 | - | increasing | #7 |
adding CoQ | increase | benefit | participants aged ≥ 65 | - | accentuated | #8 |
Advanced glycation end products (AGEs) and oxidative stress are elevated with aging and dysmetabolic conditions. Because a Mediterranean (Med) diet reduces oxidative stress, serum AGEs levels, and gene expression related to AGEs metabolism in healthy elderly people, we studied whether supplementation with coenzyme Q10 (CoQ) was of further benefit. Twenty participants aged ≥ 65 (10 men and 10 women) were randomly assigned to each of three isocaloric diets for successive periods of 4 weeks in a crossover design: Med diet, Med + CoQ, and a Western high-saturated-fat diet (SFA diet). After a 12-hour fast, volunteers consumed a breakfast with a fat composition similar to the previous diet period. Analyses included dietary AGEs consumed, serum AGEs and AGE receptor-1 (AGER1), receptor for AGEs (RAGE), glyoxalase I (GloxI), and estrogen receptor α (ERα) mRNA levels. Med diet modulated redox-state parameters, reducing AGEs levels and increasing AGER1 and GloxI mRNA levels compared with the SFA diet. This benefit was accentuated by adding CoQ, in particular, in the postprandial state. Because elevated oxidative stress/inflammation and AGEs are associated with clinical disease in aging, the enhanced protection of a Med diet supplemented with CoQ should be assessed in a larger clinical trial in which clinical conditions in aging are measured.