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The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
July 1, 2017
Roberto C Leonardo-Mendonça et al. (10 authors)
Journal ArticleRandomized Controlled TrialHuman StudyClinical
Study Details

Study Goal

The researchers aimed to determine whether melatonin's antioxidant properties could mitigate exercise-induced oxidative stress and muscle damage in athletes.

Results Summary

The study found that high-dose melatonin administration improved the circadian system in athletes, suggesting potential benefits against oxidative stress and muscle damage, though specific results are not detailed in the abstract.

Population

Athletes (24 participants)

Effective Dosage

100 mg/day

Duration

Not specified

Interactions

None mentioned

Extracted Claims (3)
InterventionDirectionEndpointPopulationDosageImpactClaim #
high doses of melatonin
increase
circadian system
athletes
-
improved
#1
melatonin
decrease
exercise-induced oxidative stress
athletes
-
has beneficial effects
#2
melatonin
decrease
muscle damage
athletes
-
has beneficial effects
#3
Abstract

Previous data showed that the administration of high doses of melatonin improved the circadian system in athletes. Here, we investigated in the same experimental paradigm whether the antioxidant properties of melatonin has also beneficial effects against exercise-induced oxidative stress and muscle damage in athletes. Twenty-four athletes were treated with 100 mg·day

Medical Subject Headings (MeSH)
Alanine TransaminaseAntioxidantsAspartate AminotransferasesAthletesBlood GlucoseCholesterolCreatine KinaseDietDietary SupplementsDouble-Blind MethodErythrocytesGlutathioneGlutathione DisulfideGlutathione PeroxidaseHumansL-Lactate DehydrogenaseLipid PeroxidationMaleMelatoninMuscle, SkeletalOxidation-ReductionOxidative StressResistance TrainingTriglyceridesYoung Adult
Study Links
Quality Scores
SafetyNot Assessed
Efficacy70/10
Quality65/10
Citation Metrics
Total Citations38
Citations/Year4.8
Relative Citation Ratio2.04
NIH Percentile75.2%
Research Impact Scores
APT Score0.75
Weight Score1.84
Normalized Score0.61
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