Neurohumoral and Endothelial Responses to Heated Water-Based Exercise in Resistant Hypertensive Patients.
Study Goal
The researchers aimed to determine the neurohumoral and endothelial responses to blood pressure-lowering effects of heated water-based exercise, including walking, in patients with resistant hypertension.
Results Summary
The study found that heated water-based exercise, including walking, significantly lowered blood pressure in resistant hypertension patients and reduced neurohumoral activation. The intervention group showed improvements in clinic and 24-hour BP measurements compared to the control group.
Population
44 patients with true resistant hypertension (mean age 53.3±0.9 years).
Effective Dosage
1-hour sessions of callisthenic exercises and walking in a heated pool, three times weekly.
Duration
12 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
heated water-based exercise (HEx) training protocol | decrease | blood pressure | resistant hypertension patients | - | BP-lowering effects | #1 |
heated water-based exercise (HEx) training protocol | decrease | neurohumoral activation | resistant hypertension patients | - | significant reduction | #2 |
BACKGROUND: The neurohumoral and endothelial responses to the blood pressure (BP) lowering effects of heated water-based exercise (HEx) in resistant hypertension (HT) patients remain undefined. METHODS AND RESULTS: We investigated these in 44 true resistant HT patients (age 53.3±0.9 years, mean±SEM). They were randomized and allocated to 2 groups, 28 to a HEx training protocol, which consisted of callisthenic exercises and walking in a heated pool for 1 h, three times weekly for 12 weeks and 16 patients to a control group maintaining their habitual activities. Measurements made before and after 12 weeks of HEx included clinic and 24-h BP, plasma levels of nitric oxide, endothelin-1, aldosterone, renin, norepinephrine and epinephrine, as well as peak V̇O CONCLUSIONS: The BP-lowering effects of HEx in resistant HT patients were accompanied by a significant reduction in the marked neurohumoral activation characterizing this clinical condition.