Reflections About Inflammatory Bowel Disease and Vitamins A and D.
Study Goal
The researchers aimed to review current evidence linking Vitamin A and Vitamin D with inflammatory bowel diseases (IBDs), focusing on their potential roles in reducing inflammation.
Results Summary
The study suggests that Vitamin A, particularly its active form retinoic acid, may be involved in immune regulation and inflammation resolution through mechanisms like growth factor-β and interleukin-10 (IL-10) release. Deficiency in Vitamin A is associated with increased disease activity in IBDs.
Population
Patients with inflammatory bowel diseases (ulcerative colitis and Crohn's disease).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin A (VA) | decrease | inflammation | patients with ulcerative colitis and Crohn's disease | - | may be associated with reduction | #1 |
Vitamin D (VD) | decrease | inflammation | patients with ulcerative colitis and Crohn's disease | - | may be associated with reduction | #2 |
retinoic acid (active form of VA) | increase | growth factor-β and release of interleukin-10 (IL-10) | - | - | may be related to | #3 |
retinoic acid (active form of VA) | decrease | resolution of the inflammation | - | - | involved with | #4 |
Vitamin A deficiency | increase | disease activity | - | - | associated with the increase | #5 |
Ulcerative colitis and Crohn's disease are two major forms of the inflammatory bowel diseases (IBDs). Vitamin A (VA) and vitamin D (VD) may be associated with reduction in inflammation in these disorders. The aim of this review was to show the current evidence that may associate VA and VD with IBDs. Data linking VA, VD, and IBDs were studied. Both VA and VD may be related to the immune system in different manners. The active form of VA, retinoic acid, may be related to the growth factor-β and release of interleukin-10 (IL-10), thus involved with the resolution of the inflammation. Its deficiency is associated with the increase of disease activity. The active form of VD is 1,25(OH)