Non-musculoskeletal benefits of vitamin D.
Study Goal
The researchers aimed to evaluate the relationships between vitamin D (from sunlight exposure) and extra-skeletal tissues, focusing on its potential benefits beyond musculoskeletal health.
Results Summary
The study found evidence suggesting vitamin D (from sunlight) plays a role in cardiovascular protection by regulating blood pressure and endothelial function, with potential benefits for extra-skeletal diseases.
Population
Adults, with special attention to those affected by extra-skeletal diseases.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D | increase | rickets | children | - | results in | #1 |
vitamin D deficiency | increase | osteomalacia | adults | - | results in | #2 |
vitamin D | increase | musculoskeletal system | humans | - | beneficial effects | #3 |
vitamin D | increase | certain physiological functions | humans | - | beneficial effects | #4 |
vitamin D | increase | outside the musculoskeletal system | - | - | additional beneficial effects | #5 |
vitamin D | neutral | blood pressure | - | - | facilitates the regulation of | #6 |
vitamin D | increase | cardiovascular protection | - | - | playing an important role in | #7 |
The aim of this study is to determine and critically evaluate the plausible relationships of vitamin D with extra-skeletal tissues in humans. Severe vitamin D deficiency results in rickets in children and osteomalacia in adults; these beneficial effects in the musculoskeletal system and certain physiological functions are well understood. Nevertheless, mounting reports support additional beneficial effects of vitamin D, outside the musculoskeletal system. This review explores the recent advances in knowledge about the non-skeletal effects of vitamin D. Peer-reviewed papers were extracted from research databases using key words, to assess correlations between vitamin D and extra-skeletal diseases and conditions. As per the guidelines of the Preferred Reporting Items for Systematic Reviews (PRISMA); general interpretations of results are included; taking into consideration the broader evidence and implications. This review summarizes current knowledge of the effects of vitamin D status on extra-skeletal tissues with special attention given to relationships between vitamin D status and various diseases commonly affecting adults; the effects of intervention with vitamin D and exposure to sunlight. Evidence suggests that vitamin D facilitates the regulation of blood pressure; and cardiac; endothelial; and smooth muscle cell functions; playing an important role in cardiovascular protection. In addition; 1,25(OH)